Non-Destructive Analysis of Chlorpheniramine Maleate Tablets and Granules by Chemometrics-Assisted Attenuated Total Reflectance Infrared Spectroscopy
2
Issued Date
2022-08-01
Resource Type
eISSN
14203049
Scopus ID
2-s2.0-85132860979
Pubmed ID
35744885
Journal Title
Molecules
Volume
27
Issue
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Molecules Vol.27 No.12 (2022)
Suggested Citation
Phechkrajang C., Khongkaew P., Limwikrant W., Jaturanpinyo M. Non-Destructive Analysis of Chlorpheniramine Maleate Tablets and Granules by Chemometrics-Assisted Attenuated Total Reflectance Infrared Spectroscopy. Molecules Vol.27 No.12 (2022). doi:10.3390/molecules27123760 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/83662
Title
Non-Destructive Analysis of Chlorpheniramine Maleate Tablets and Granules by Chemometrics-Assisted Attenuated Total Reflectance Infrared Spectroscopy
Author's Affiliation
Other Contributor(s)
Abstract
Non-destructive analysis of chlorpheniramine maleate (CPM), pharmaceutical tablets, and granules was conducted by chemometrics-assisted attenuated total reflectance infrared spectroscopy (ATR-IR). For tablets, an optimum PLSR model with eight latent factors was obtained from area-normalized and standard normal variate (SNV) pretreated ATR-IR spectral data with correlation coefficients (R2) of calibration and cross-validation of 0.9716 and 0.9602, respectively. The model capability for the 42 test set samples was proven with R2 between the reference and model prediction values of 0.9632, and a root-mean-square error of prediction (RMSEP) of 1.7786. The successive PLSR model for granules was constructed from SNV and first derivative pretreated ATR-IR spectral data with two latent factors and correlation coefficients (R2) of calibration and cross-validation of 0.9577 and 0.9450, respectively.