The antioxidant activities and inhibitory effects on α-glucosidase and α-Amylase of ethanolic and aqueous extracts from various parts of Thai Caesalpinia sappan L.
Issued Date
2023-01-01
Resource Type
ISSN
15131874
Scopus ID
2-s2.0-85170236766
Journal Title
ScienceAsia
Volume
49
Start Page
618
End Page
626
Rights Holder(s)
SCOPUS
Bibliographic Citation
ScienceAsia Vol.49 (2023) , 618-626
Suggested Citation
Boonmee A., Moonrungsee N., Kasemsuk T., Puckdee W., Komonpanich P., Kunsook C., Khamchatra N.M., Nakeim S., Khamchutra A., Suninthaboonrana R., Chairatana P., Toviwek B., Pongprayoon P., Suwancharoen S. The antioxidant activities and inhibitory effects on α-glucosidase and α-Amylase of ethanolic and aqueous extracts from various parts of Thai Caesalpinia sappan L.. ScienceAsia Vol.49 (2023) , 618-626. 626. doi:10.2306/scienceasia1513-1874.2023.059 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/90047
Title
The antioxidant activities and inhibitory effects on α-glucosidase and α-Amylase of ethanolic and aqueous extracts from various parts of Thai Caesalpinia sappan L.
Other Contributor(s)
Abstract
Caesalpinia sappan (CS) has been commonly used in beverage and folk medicine in China and ASEAN countries because of its various therapeutic properties. Only the heartwood has long been used in traditional medicines due to the presence of high concentration of brazilin (one of the most important bioactive compounds), whereas the other parts are limited in use. Thus, this work aimed to investigate ways of utilizing other parts of CS. This information is important for further use of other CS parts to promote zero waste and hence sustainable resource utilization. Herein, the crude ethanolic (CEE) and crude aqueous (CAE) extracts from twelve parts of CS were evaluated for their biological activities for the first time. Our work demonstrates that not only the heartwood, but also other parts of CS exhibit interesting biological activities. CAE from heartwood of branches exhibits the highest antioxidant activity, which is higher than that of the positive control, butylated hydroxytoluene. CEE from florets shows the highest inhibitory effect against α-Amylase, while CAE of barks shows better α-glucosidase inhibitory activity than the existing glucosidase inhibitor (acarbose). Molecular docking of brazilin (key bioactive compound) to both α-Amylase and glucosidase can also confirm the tight binding of brazilin to α-glucosidase.