The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Mpox/Monkeypox Virus
1
Issued Date
2023-01-01
Resource Type
ISSN
15356760
eISSN
24701246
Scopus ID
2-s2.0-85168750637
Journal Title
Applied Biosafety
Rights Holder(s)
SCOPUS
Bibliographic Citation
Applied Biosafety (2023)
Suggested Citation
Blacksell S.D., Dhawan S., Kusumoto M., Khanh Le K., Summermatter K., O'Keefe J., Kozlovac J., Al Muhairi S.S., Sendow I., Scheel C.M., Ahumibe A., Masuku Z.M., Bennett A.M., Kojima K., Harper D.R., Hamilton K. The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Mpox/Monkeypox Virus. Applied Biosafety (2023). doi:10.1089/apb.2022.0045 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/89156
Title
The Biosafety Research Road Map: The Search for Evidence to Support Practices in the Laboratory—Mpox/Monkeypox Virus
Author's Affiliation
World Organisation for Animal Health (WOAH)
Badan Riset dan Inovasi Nasional
UK Health Security Agency
Mahidol Oxford Tropical Medicine Research Unit
Nigeria Centre for Disease Control
National Institute for Communicable Diseases
Organisation Mondiale de la Santé
Centers for Disease Control and Prevention
Chatham House
University of Bern
Nuffield Department of Medicine
USDA ARS Beltsville Agricultural Research Center
Abu Dhabi Agriculture and Food Safety Authority
Ministry for Primary Industries
Badan Riset dan Inovasi Nasional
UK Health Security Agency
Mahidol Oxford Tropical Medicine Research Unit
Nigeria Centre for Disease Control
National Institute for Communicable Diseases
Organisation Mondiale de la Santé
Centers for Disease Control and Prevention
Chatham House
University of Bern
Nuffield Department of Medicine
USDA ARS Beltsville Agricultural Research Center
Abu Dhabi Agriculture and Food Safety Authority
Ministry for Primary Industries
Other Contributor(s)
Abstract
Introduction: The virus formerly known as monkeypox virus, now called mpoxv, belongs to the Orthopoxvirus genus and can cause mpox disease through both animal-to-human and human-to-human transmission. The unexpected spread of mpoxv among humans has prompted the World Health Organization (WHO) to declare a Public Health Emergency of International Concern (PHEIC). Methods: We conducted a literature search to identify the gaps in biosafety, focusing on five main areas: how the infection enters the body and spreads, how much of the virus is needed to cause infection, infections acquired in the lab, accidental release of the virus, and strategies for disinfecting and decontaminating the area. Discussion: The recent PHEIC has shown that there are gaps in our knowledge of biosafety when it comes to mpoxv. We need to better understand where this virus might be found, how much of it can spread from person-to-person, what are the effective control measures, and how to safely clean up contaminated areas. By gathering more biosafety evidence, we can make better decisions to protect people from this zoonotic agent, which has recently become more common in the human population.