Pharmacokinetic considerations in seasonal malaria chemoprevention
3
item.page.dc.date.issued
2022-08-01
item.page.dc.type
item.page.dc.identifier.issn
14714922
item.page.dc.identifier.eissn
14715007
item.page.dc.identifier.doi
item.page.dc.identifier.scopus
2-s2.0-85131809192
item.page.dc.identifier.pmid
35688778
item.page.oaire.citation.title
Trends in Parasitology
item.page.oaire.citation.volume
38
item.page.oaire.citation.issue
8
item.page.oaire.citation.startPage
673
item.page.oaire.citation.endPage
682
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SCOPUS
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Trends in Parasitology Vol.38 No.8 (2022) , 673-682
punsarn.item.page.citation
Chotsiri P., White N.J., Tarning J. Pharmacokinetic considerations in seasonal malaria chemoprevention. Trends in Parasitology Vol.38 No.8 (2022) , 673-682. 682. doi:10.1016/j.pt.2022.05.003 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/84946
item.page.dc.title
Pharmacokinetic considerations in seasonal malaria chemoprevention
item.page.dc.contributor.author
item.page.oairecerif.author.affiliation
item.page.dc.contributor.other
item.page.dc.description.abstract
African children under 5 years of age bear the main burden of global malaria mortality. Seasonal malaria chemoprevention (SMC) with sulfadoxine-pyrimethamine (SP) plus amodiaquine (AQ) given monthly during the rainy season is a highly effective malaria intervention for children aged between 3 months and 5 years living in the Sahel region, a region of intense but seasonal malaria transmission. This intervention is now being considered for other regions of Africa where malaria parasites are more drug resistant. Dihydroartemisinin-piperaquine (DP), an artemisinin-based combination therapy (ACT), has proved to be highly effective and well tolerated in intermittent preventive treatment in pregnant women and children. This combination may be a suitable alternative for SMC. Understanding the safety, pharmacokinetic and pharmacodynamic properties of antimalarial combination therapies is crucial in optimising dosing.