Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study
Issued Date
2024-09-01
Resource Type
ISSN
15691993
eISSN
18735010
Scopus ID
2-s2.0-85202462521
Pubmed ID
39191560
Journal Title
Journal of Cystic Fibrosis
Volume
23
Issue
5
Start Page
815
End Page
822
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Cystic Fibrosis Vol.23 No.5 (2024) , 815-822
Suggested Citation
Semenchuk J., Naito Y., Charman S.C., Carr S.B., Cheng S.Y., Marshall B.C., Faro A., Elbert A., Gutierrez H.H., Goss C.H., Karadag B., Burgel P.R., Colombo C., Salvatore M., Padoan R., Daneau G., Harutyunyan S., Kashirskaya N., Kirwan L., Middleton P.G., Ruseckaite R., de Monestrol I., Naehrlich L., Mondejar-Lopez P., Jung A., van Rens J., Bakkeheim E., Orenti A., Zomer-van Ommen D., da Silva-Filho L.V.R., Fernandes F.F., Zampoli M., Stephenson A.L., Kasmi I., Drali O., Burghart S., Lakatos-Krepcik A., Eder J., Jaksch P., Kainz K., Kallinger M., Leitner A., Mozdzen M., Pfleger A., Renner S., Stadlinger M., Thir C., Nuriyev E., Boboli H., De Wachter E., Dupont L., Gohy S., Hanssens L., Knoop C., Lammertyn E., Nowé V., Pirson J., Thimmesch M., Van Braeckel E., Van Hoorenbeeck K., Vanderhelst E., Filho E.P., Athanazio R.A., Martins V.d.C., Duarte M.C., Monte L.d.F.V., de Fuccio M.B., Knabben A.d.S.C., Melloti R., Meneses D.G., Petrova G., Tješić-Drinković D., Dugac A.V., Bambir I., Yiallouros P., Bilkova A., Drevinek P., Macek M., Olesen H.V., Pressler T., Fouda E.M., Nasr S., Weldetsadik A.Y., Al-iede M., Abdrakhmanov O., Corvol H., Lemonnier-Videau L., Abely M., Piccini C.B., Belleguic C., Bihouee T., Billon Y., Bui S., Camara B., Cheraud M.C., Chiron R., Duet E.C., Cosson L., Dalphin M.L., Boucher I.D. Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study. Journal of Cystic Fibrosis Vol.23 No.5 (2024) , 815-822. 822. doi:10.1016/j.jcf.2024.07.019 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101284
Title
Impact of COVID-19 infection on lung function and nutritional status amongst individuals with cystic fibrosis: A global cohort study
Author(s)
Semenchuk J.
Naito Y.
Charman S.C.
Carr S.B.
Cheng S.Y.
Marshall B.C.
Faro A.
Elbert A.
Gutierrez H.H.
Goss C.H.
Karadag B.
Burgel P.R.
Colombo C.
Salvatore M.
Padoan R.
Daneau G.
Harutyunyan S.
Kashirskaya N.
Kirwan L.
Middleton P.G.
Ruseckaite R.
de Monestrol I.
Naehrlich L.
Mondejar-Lopez P.
Jung A.
van Rens J.
Bakkeheim E.
Orenti A.
Zomer-van Ommen D.
da Silva-Filho L.V.R.
Fernandes F.F.
Zampoli M.
Stephenson A.L.
Kasmi I.
Drali O.
Burghart S.
Lakatos-Krepcik A.
Eder J.
Jaksch P.
Kainz K.
Kallinger M.
Leitner A.
Mozdzen M.
Pfleger A.
Renner S.
Stadlinger M.
Thir C.
Nuriyev E.
Boboli H.
De Wachter E.
Dupont L.
Gohy S.
Hanssens L.
Knoop C.
Lammertyn E.
Nowé V.
Pirson J.
Thimmesch M.
Van Braeckel E.
Van Hoorenbeeck K.
Vanderhelst E.
Filho E.P.
Athanazio R.A.
Martins V.d.C.
Duarte M.C.
Monte L.d.F.V.
de Fuccio M.B.
Knabben A.d.S.C.
Melloti R.
Meneses D.G.
Petrova G.
Tješić-Drinković D.
Dugac A.V.
Bambir I.
Yiallouros P.
Bilkova A.
Drevinek P.
Macek M.
Olesen H.V.
Pressler T.
Fouda E.M.
Nasr S.
Weldetsadik A.Y.
Al-iede M.
Abdrakhmanov O.
Corvol H.
Lemonnier-Videau L.
Abely M.
Piccini C.B.
Belleguic C.
Bihouee T.
Billon Y.
Bui S.
Camara B.
Cheraud M.C.
Chiron R.
Duet E.C.
Cosson L.
Dalphin M.L.
Boucher I.D.
Naito Y.
Charman S.C.
Carr S.B.
Cheng S.Y.
Marshall B.C.
Faro A.
Elbert A.
Gutierrez H.H.
Goss C.H.
Karadag B.
Burgel P.R.
Colombo C.
Salvatore M.
Padoan R.
Daneau G.
Harutyunyan S.
Kashirskaya N.
Kirwan L.
Middleton P.G.
Ruseckaite R.
de Monestrol I.
Naehrlich L.
Mondejar-Lopez P.
Jung A.
van Rens J.
Bakkeheim E.
Orenti A.
Zomer-van Ommen D.
da Silva-Filho L.V.R.
Fernandes F.F.
Zampoli M.
Stephenson A.L.
Kasmi I.
Drali O.
Burghart S.
Lakatos-Krepcik A.
Eder J.
Jaksch P.
Kainz K.
Kallinger M.
Leitner A.
Mozdzen M.
Pfleger A.
Renner S.
Stadlinger M.
Thir C.
Nuriyev E.
Boboli H.
De Wachter E.
Dupont L.
Gohy S.
Hanssens L.
Knoop C.
Lammertyn E.
Nowé V.
Pirson J.
Thimmesch M.
Van Braeckel E.
Van Hoorenbeeck K.
Vanderhelst E.
Filho E.P.
Athanazio R.A.
Martins V.d.C.
Duarte M.C.
Monte L.d.F.V.
de Fuccio M.B.
Knabben A.d.S.C.
Melloti R.
Meneses D.G.
Petrova G.
Tješić-Drinković D.
Dugac A.V.
Bambir I.
Yiallouros P.
Bilkova A.
Drevinek P.
Macek M.
Olesen H.V.
Pressler T.
Fouda E.M.
Nasr S.
Weldetsadik A.Y.
Al-iede M.
Abdrakhmanov O.
Corvol H.
Lemonnier-Videau L.
Abely M.
Piccini C.B.
Belleguic C.
Bihouee T.
Billon Y.
Bui S.
Camara B.
Cheraud M.C.
Chiron R.
Duet E.C.
Cosson L.
Dalphin M.L.
Boucher I.D.
Author's Affiliation
Universidade Federal de Catalão
University of Cyprus Medical School
St. Paul‘s Hospital Millennium Medical College
Kepler Universitätsklinikum
Moscow Regional Research and Clinical Institute
Oslo Universitetssykehus
Klinikum Wels - Grieskirchen GmbH
Yerevan State University
Hospital Infantil Joana de Gusmao
Sint-Vincentiusziekenhuis
Universitair Ziekenhuis Brussel
Universitair Ziekenhuis Gent
Hôpital Erasme
Jordan University Hospital
UW Medical Center – Montlake
KBC Zagreb
Centre Hospitalier Universitaire de Montpellier
Institut Cochin
KU Leuven– University Hospital Leuven
Centre Hospitalier Universitaire de Nice
Università degli Studi di Milano
Medizinische Universität Wien Universitätsklinik für Kinder- und Jugendheilkunde
Hospital Clínico Universitario Virgen de la Arrixaca
Centre Hospitalier Universitaire de Rennes
CHU de Nantes
Centre Hospitalier Universitaire de Besançon
The University of Alabama at Birmingham
Allgemeines KrankenHaus Wien
University of Michigan, Ann Arbor
Aarhus Universitetshospital
Hospital Universitaire des Enfants Reine Fabiola
Fakultní Nemocnice v Motole
Royal Brompton & Harefield NHS Foundation Trust
Johannes Kepler University Linz
Centre Hospitalier Universitaire de Bordeaux
CHV Centre Hospitalier de Versailles
CHU de Nancy
CHU de Reims
Monash University
Karolinska Universitetssjukhuset
Justus-Liebig-Universität Gießen
St. Michael's Hospital, Toronto
Centre Hospitalier Universitaire de Liege
Centre Hospitalier Regional et Universitaire de Tours
Ain Shams University
Universitair Ziekenhuis Antwerpen
Hôpital Armand-Trousseau
Red Cross War Memorial Children's Hospital
Cliniques Universitaires Saint-Luc
University Hospital Alexandrovska
Istituto Superiore Di Sanita
Medizinische Universitat Innsbruck
Universidade de São Paulo
Centre Hospitalier Universitaire de Clermont-Ferrand
Rigshospitalet
Medizinische Universität Graz
Centre Hospitalier Universitaire de Grenoble
University College Dublin
Marmara Üniversitesi Tip Fakültesi
Westmead Hospital
Université Fédérale de Sergipe
Kinderspital Zürich
Klinik Ottakring
Universidade Federal de Juiz de Fora
ETPI Children Clinical Hospital
Monika Pell
Health services research
CHC Clinique du Montlégia
"Mother Thereza" Hospital Center
Brussels; Association Muco A.S.B.L. – Mucovereniging V.Z.W.
CHR Citadelle
Hospital Universitário João de Barros Barreto
Scientific Board
Hospital Nereu Ramos
Júlia Kubitschek Hospital (FHEMIG)
Cystic Fibrosis Canada
Hospital da Criança de Brasília José Alencar
Hospital Infantil Nossa Senhora da Glória
Krankenhaus Hietzing
SignalTrust UK
C. H. U. de Hussein-Dey
Dutch CF Foundation NCFS
Scientific Center of Pediatrics and Children's Surgery
Vaincre la Mucoviscidose
Cystic Fibrosis Foundation
University of Cyprus Medical School
St. Paul‘s Hospital Millennium Medical College
Kepler Universitätsklinikum
Moscow Regional Research and Clinical Institute
Oslo Universitetssykehus
Klinikum Wels - Grieskirchen GmbH
Yerevan State University
Hospital Infantil Joana de Gusmao
Sint-Vincentiusziekenhuis
Universitair Ziekenhuis Brussel
Universitair Ziekenhuis Gent
Hôpital Erasme
Jordan University Hospital
UW Medical Center – Montlake
KBC Zagreb
Centre Hospitalier Universitaire de Montpellier
Institut Cochin
KU Leuven– University Hospital Leuven
Centre Hospitalier Universitaire de Nice
Università degli Studi di Milano
Medizinische Universität Wien Universitätsklinik für Kinder- und Jugendheilkunde
Hospital Clínico Universitario Virgen de la Arrixaca
Centre Hospitalier Universitaire de Rennes
CHU de Nantes
Centre Hospitalier Universitaire de Besançon
The University of Alabama at Birmingham
Allgemeines KrankenHaus Wien
University of Michigan, Ann Arbor
Aarhus Universitetshospital
Hospital Universitaire des Enfants Reine Fabiola
Fakultní Nemocnice v Motole
Royal Brompton & Harefield NHS Foundation Trust
Johannes Kepler University Linz
Centre Hospitalier Universitaire de Bordeaux
CHV Centre Hospitalier de Versailles
CHU de Nancy
CHU de Reims
Monash University
Karolinska Universitetssjukhuset
Justus-Liebig-Universität Gießen
St. Michael's Hospital, Toronto
Centre Hospitalier Universitaire de Liege
Centre Hospitalier Regional et Universitaire de Tours
Ain Shams University
Universitair Ziekenhuis Antwerpen
Hôpital Armand-Trousseau
Red Cross War Memorial Children's Hospital
Cliniques Universitaires Saint-Luc
University Hospital Alexandrovska
Istituto Superiore Di Sanita
Medizinische Universitat Innsbruck
Universidade de São Paulo
Centre Hospitalier Universitaire de Clermont-Ferrand
Rigshospitalet
Medizinische Universität Graz
Centre Hospitalier Universitaire de Grenoble
University College Dublin
Marmara Üniversitesi Tip Fakültesi
Westmead Hospital
Université Fédérale de Sergipe
Kinderspital Zürich
Klinik Ottakring
Universidade Federal de Juiz de Fora
ETPI Children Clinical Hospital
Monika Pell
Health services research
CHC Clinique du Montlégia
"Mother Thereza" Hospital Center
Brussels; Association Muco A.S.B.L. – Mucovereniging V.Z.W.
CHR Citadelle
Hospital Universitário João de Barros Barreto
Scientific Board
Hospital Nereu Ramos
Júlia Kubitschek Hospital (FHEMIG)
Cystic Fibrosis Canada
Hospital da Criança de Brasília José Alencar
Hospital Infantil Nossa Senhora da Glória
Krankenhaus Hietzing
SignalTrust UK
C. H. U. de Hussein-Dey
Dutch CF Foundation NCFS
Scientific Center of Pediatrics and Children's Surgery
Vaincre la Mucoviscidose
Cystic Fibrosis Foundation
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Factors associated with severe COVID-19 infection have been identified; however, the impact of infection on longer-term outcomes is unclear. The objective of this study was to examine the impact of COVID-19 infection on the trajectory of lung function and nutritional status in people with cystic fibrosis (pwCF). Methods: This is a retrospective global cohort study of pwCF who had confirmed COVID-19 infection diagnosed between January 1, 2020 and December 31, 2021. Forced expiratory volume in one second percent predicted (ppFEV1) and body mass index (BMI) twelve months prior to and following a diagnosis of COVID-19 were recorded. Change in mean ppFEV1 and BMI were compared using a t-test. A linear mixed-effects model was used to estimate change over time and to compare the rate of change before and after infection. Results: A total of 6,500 cases of COVID-19 in pwCF from 33 countries were included for analysis. The mean difference in ppFEV1 pre- and post-infection was 1.4 %, (95 % CI 1.1, 1.7). In those not on modulators, the difference in rate of change pre- and post-infection was 1.34 %, (95 % CI -0.88, 3.56) per year (p = 0.24) and -0.74 % (-1.89, 0.41) per year (p = 0.21) for those on elexacaftor/tezacaftor/ivacaftor. No clinically significant change was noted in BMI or BMI percentile before and after COVID-19 infection. Conclusions: No clinically meaningful impact on lung function and BMI trajectory in the year following infection with COVID-19 was identified. This work highlights the ability of the global CF community to unify and address critical issues facing pwCF.