Factors predicting fluid-free retina and complete polypoidal regression in polypoidal choroidal vasculopathy eyes receiving 2-mg aflibercept treatments
Issued Date
2026-01-01
Resource Type
eISSN
21620989
Scopus ID
2-s2.0-105032266047
Journal Title
Asia Pacific Journal of Ophthalmology
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asia Pacific Journal of Ophthalmology (2026)
Suggested Citation
Chaikitmongkol V., Somkuna T., Patikulsila D., Ruamviboonsuk P., Jirarattanasopa P., Srisomboon T., Narongchai C., Ratanasukon M., Bhurayanontachai P., Kunavisarut P., Watanachai N., Choovuthayakorn J., Chotcomwongse P., Sangkaew A., Ingviya T., Bressler N.M. Factors predicting fluid-free retina and complete polypoidal regression in polypoidal choroidal vasculopathy eyes receiving 2-mg aflibercept treatments. Asia Pacific Journal of Ophthalmology (2026). doi:10.1016/j.apjo.2026.100298 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/115676
Title
Factors predicting fluid-free retina and complete polypoidal regression in polypoidal choroidal vasculopathy eyes receiving 2-mg aflibercept treatments
Corresponding Author(s)
Other Contributor(s)
Abstract
Purpose To determine predictive factors for fluid-free retina and complete polypoidal choroidal vasculopathy (PCV) regression following 1-year aflibercept monotherapy in PCV. Methods Multicenter, retrospective cohort of treatment-naïve PCV eyes receiving 2-mg aflibercept treatments for 1 year from 2015 to 2018 collected demographic data, de-identified fundus photography, optical coherence tomography (OCT), and indocyanine green angiography (ICGA) images at baseline and 1-year of study eyes were graded to identify baseline features and outcomes. Results Of 100 study eyes, mean age [SD] was 63.8 [8] years; 100% were Thai patients. At 1 year, eighty-five eyes (85%) had fluid-free retina; 48 eyes (48%) had complete polypoidal regression. Multivariate analyses showed baseline OCT and ICGA features associated with 1-year outcomes: sharply-peaked PED with/without double-layer sign on OCT and smaller lesion size on ICGA (<1 disc diameter) were associated with fluid-free retina (OR 6.57; 95%CI 1.27–34.10, and OR 7.86; 95%CI 1.33–46.54, respectively). Multilobulated PED on OCT was associated with poor (20/200 or worse) final VA (OR 4.53; 95%CI 1.33–15.36). Smaller number (1−5) of polypoidal lesions on ICGA was associated with complete polypoidal regression (OR 4.87; 95%CI 1.44–16.43) Conclusion Results suggest baseline OCT and ICGA features could predict fluid-free retina and complete polypoidal regression following aflibercept monotherapy.