Inhibitory effects against zoonotic bacteria by Oroxylum indicum ointment and effects to dog wound
Issued Date
2024-01-01
Resource Type
ISSN
22314040
eISSN
09762094
Scopus ID
2-s2.0-85199456244
Journal Title
Journal of Advanced Pharmaceutical Technology and Research
Volume
15
Issue
3
Start Page
156
End Page
160
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Advanced Pharmaceutical Technology and Research Vol.15 No.3 (2024) , 156-160
Suggested Citation
Sithisarn P., Rojsanga P., Ruenraroengsak P., Sithisarn P. Inhibitory effects against zoonotic bacteria by Oroxylum indicum ointment and effects to dog wound. Journal of Advanced Pharmaceutical Technology and Research Vol.15 No.3 (2024) , 156-160. 160. doi:10.4103/JAPTR.JAPTR_97_24 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100067
Title
Inhibitory effects against zoonotic bacteria by Oroxylum indicum ointment and effects to dog wound
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Author's Affiliation
Corresponding Author(s)
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Abstract
A topical antimicrobial ointment was developed from the fruit extract of Oroxylum indicum and was evaluated for its antibacterial and wound-healing effects and acute toxicity in animal models. O. indicum fruit and seed extracts exhibited antibacterial activities against clinically isolated bacteria and showed in vitro antioxidant activities. To develop a topical antimicrobial ointment from the fruit extract of O. indicum and evaluate for its antibacterial and wound-healing effects. O. indicum fruit extract ointment was prepared and qualitatively controlled. Acute toxicity of the extract was evaluated in the animal model. Antibacterial effects and healing effects of the ointment to the dog wound were investigated. The results are expressed as mean ± standard deviation. The ointment exhibited in vitro antibacterial effects. A single daily application of the ointment to a dog's wound exhibited a wound-healing effect with complete epithelialization within 7 days while the wound was completely healed with the removal of the scabs, the size was decreased to 14% of the original size within 12 days. The ointment was found no acute toxicity in the animal model. O. indicum ointment promoted in vitro antibacterial activity and wound-healing effect in dogs with no acute toxicity.