High parathyroid hormone level as a marker of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis
Issued Date
2023-08-01
Resource Type
ISSN
18714021
eISSN
18780334
Scopus ID
2-s2.0-85164449628
Journal Title
Diabetes and Metabolic Syndrome: Clinical Research and Reviews
Volume
17
Issue
8
Rights Holder(s)
SCOPUS
Bibliographic Citation
Diabetes and Metabolic Syndrome: Clinical Research and Reviews Vol.17 No.8 (2023)
Suggested Citation
Jaroenlapnopparat A., Rittiphairoj T., Chaisidhivej N., Walker B., Charoenngam N. High parathyroid hormone level as a marker of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis. Diabetes and Metabolic Syndrome: Clinical Research and Reviews Vol.17 No.8 (2023). doi:10.1016/j.dsx.2023.102827 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87992
Title
High parathyroid hormone level as a marker of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: A systematic review and meta-analysis
Other Contributor(s)
Abstract
Background and aims: Studies have suggested that high parathyroid hormone (PTH) was associated with non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH), although the results from existing studies are inconsistent. Using systematic review and meta-analysis, we aimed to determine the association of PTH with NAFLD and NASH. Methods: Potentially eligible studies were identified from Embase and Medline databases from using search strategy consisting of terms for “NAFLD/NASH”, and “PTH”. Eligible study must consist of one group of patients with NAFLD/NASH and another group without NAFLD/NASH. The study must provide mean ± SD PTH in both groups. We extracted such data to calculate mean difference (MD). Pooled MD was then calculated by combining MDs of each study using random-effects model. Funnel plot was used to assess for the presence of publication bias. Results: A total of 388 articles were identified. After systematic review, 12 studies fulfilled the eligibility criteria and were included into the meta-analysis. The meta-analysis of 10 studies revealed the significant association between high PTH and NAFLD, with the pooled MD of 5.479 (95%CI 0.947–10.011, I2 82.4%). The funnel plot was symmetric and did not suggest publication bias. The meta-analysis of 4 studies revealed the non-significant association between high PTH and NASH, with the pooled MD of 11.955 (95%CI -4.703 – 28.614, I2 81.0%). Conclusions: High PTH level is significantly associated with NAFLD and can be used as a marker of NAFLD. However, high PTH level is non-significantly associated with NASH. Further studies are needed to increase the sample size and eliminate the confounding factors.