Using the Proteomics Toolbox to Resolve Topology and Dynamics of Compartmentalized cAMP Signaling
Issued Date
2023-03-01
Resource Type
ISSN
16616596
eISSN
14220067
Scopus ID
2-s2.0-85149848185
Pubmed ID
36902098
Journal Title
International Journal of Molecular Sciences
Volume
24
Issue
5
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Molecular Sciences Vol.24 No.5 (2023)
Suggested Citation
Kovanich D., Low T.Y., Zaccolo M. Using the Proteomics Toolbox to Resolve Topology and Dynamics of Compartmentalized cAMP Signaling. International Journal of Molecular Sciences Vol.24 No.5 (2023). doi:10.3390/ijms24054667 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/81636
Title
Using the Proteomics Toolbox to Resolve Topology and Dynamics of Compartmentalized cAMP Signaling
Author(s)
Other Contributor(s)
Abstract
cAMP is a second messenger that regulates a myriad of cellular functions in response to multiple extracellular stimuli. New developments in the field have provided exciting insights into how cAMP utilizes compartmentalization to ensure specificity when the message conveyed to the cell by an extracellular stimulus is translated into the appropriate functional outcome. cAMP compartmentalization relies on the formation of local signaling domains where the subset of cAMP signaling effectors, regulators and targets involved in a specific cellular response cluster together. These domains are dynamic in nature and underpin the exacting spatiotemporal regulation of cAMP signaling. In this review, we focus on how the proteomics toolbox can be utilized to identify the molecular components of these domains and to define the dynamic cellular cAMP signaling landscape. From a therapeutic perspective, compiling data on compartmentalized cAMP signaling in physiological and pathological conditions will help define the signaling events underlying disease and may reveal domain-specific targets for the development of precision medicine interventions.