Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome
Issued Date
2022-01-01
Resource Type
ISSN
10428194
eISSN
10292403
Scopus ID
2-s2.0-85126237750
Pubmed ID
35258401
Journal Title
Leukemia and Lymphoma
Volume
63
Issue
8
Start Page
1907
End Page
1916
Rights Holder(s)
SCOPUS
Bibliographic Citation
Leukemia and Lymphoma Vol.63 No.8 (2022) , 1907-1916
Suggested Citation
Xie W., Raess P.W., Dunlap J., Hoyos C.M., Li H., Li P., Swords R., Olson S.B., Yang F., Anekpuritanang T., Hu S., Wiszniewska J., Fan G., Press R.D., Moore S.R. Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome. Leukemia and Lymphoma Vol.63 No.8 (2022) , 1907-1916. 1916. doi:10.1080/10428194.2022.2047672 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/83919
Title
Adult acute myeloid leukemia patients with NUP98 rearrangement have frequent cryptic translocations and unfavorable outcome
Other Contributor(s)
Abstract
Acute myeloid leukemia (AML) with NUP98 rearrangement (AML-NUP98) has been uncommonly reported in adults, and its incidence in our institution is ∼2.5%. There were four men and five women with a median age of 49 years, among which six cases were de novo AML and three were therapy-related. Five cases were AML with minimal differentiation or without maturation, followed by four with monocytic differentiation. NUP98 rearrangement was confirmed in all cases by FISH, and five cases showed cryptic translocations. The median overall survival (OS) was 13 months, shorter than that of AML-NPM1 (p < 0.05), and similar to that in AML-KMT2A patients in our institution. The unfavorable OS was further confirmed by comparing to AML patients in TCGA database. In conclusion, adult AML-NUP98 is associated with cryptic translocations and an unfavorable outcome. Our study suggests that incorporating the NUP98 probe into AML FISH panels are warranted to improve clinical management.