Genomic insights into ceftazidime resistance in Burkholderia pseudomallei: discovery of A172T mutation and palindromic GC-rich repeat sequences facilitating penA duplication and amplification
Issued Date
2025-08-06
Resource Type
eISSN
10986596
Scopus ID
2-s2.0-105013156958
Pubmed ID
40689768
Journal Title
Antimicrobial Agents and Chemotherapy
Volume
69
Issue
8
Rights Holder(s)
SCOPUS
Bibliographic Citation
Antimicrobial Agents and Chemotherapy Vol.69 No.8 (2025) , e0022025
Suggested Citation
Tuanyok A., Nakajima C., Noll T., Khan M.S.R., Khrongsee P., Yowell C.A., Xiao Y.P., Wuthiekanun V., Chantratita N., Heine H., Subramaniam K., Suzuki Y., Limmathurotsakul D., Mergia A. Genomic insights into ceftazidime resistance in Burkholderia pseudomallei: discovery of A172T mutation and palindromic GC-rich repeat sequences facilitating penA duplication and amplification. Antimicrobial Agents and Chemotherapy Vol.69 No.8 (2025) , e0022025. doi:10.1128/aac.00220-25 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111743
Title
Genomic insights into ceftazidime resistance in Burkholderia pseudomallei: discovery of A172T mutation and palindromic GC-rich repeat sequences facilitating penA duplication and amplification
Corresponding Author(s)
Other Contributor(s)
Abstract
Ceftazidime (CAZ) resistance in Burkholderia pseudomallei, the causative agent of melioidosis, complicates treatment in endemic regions. This study identified a novel A172T mutation and other known penA mutations as critical contributors to CAZ resistance in a large Thai strain collection. Frequent gene duplication and amplification of penA, likely driven by Palindromic GC-Rich Repeat Sequences, highlights the urgent need for rapid diagnostics and optimized treatment strategies to manage this life-threatening disease effectively.