Dosing of Mood Stabilizers for Bipolar Disorder Patients in the Research on Asian Psychotropic Prescription Patterns Consortium Study
Issued Date
2022-05-01
Resource Type
ISSN
02710749
eISSN
1533712X
Scopus ID
2-s2.0-85129373833
Pubmed ID
35384905
Journal Title
Journal of Clinical Psychopharmacology
Volume
42
Issue
3
Start Page
293
End Page
297
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Psychopharmacology Vol.42 No.3 (2022) , 293-297
Suggested Citation
Wang Y., Chew Q.H., Lin S.K., Yang S.Y., Ouyang W.C., Chen C.K., Park S.C., Jang O.J., Park J.H., Chee K.Y., Ding K.S., Chong J., Zhang L., Li K., Zhu X., Jatchavala C., Pariwatcharakul P., Kallivayalil R.A., Grover S., Avasthi A., Ansari M., Maramis M.M., Aung P.P., Sartorius N., Xiang Y.T., Tan C.H., Chong M.Y., Park Y.C., Kato T.A., Shinfuku N., Baldessarini R.J., Sim K. Dosing of Mood Stabilizers for Bipolar Disorder Patients in the Research on Asian Psychotropic Prescription Patterns Consortium Study. Journal of Clinical Psychopharmacology Vol.42 No.3 (2022) , 293-297. 297. doi:10.1097/JCP.0000000000001549 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85918
Title
Dosing of Mood Stabilizers for Bipolar Disorder Patients in the Research on Asian Psychotropic Prescription Patterns Consortium Study
Author(s)
Wang Y.
Chew Q.H.
Lin S.K.
Yang S.Y.
Ouyang W.C.
Chen C.K.
Park S.C.
Jang O.J.
Park J.H.
Chee K.Y.
Ding K.S.
Chong J.
Zhang L.
Li K.
Zhu X.
Jatchavala C.
Pariwatcharakul P.
Kallivayalil R.A.
Grover S.
Avasthi A.
Ansari M.
Maramis M.M.
Aung P.P.
Sartorius N.
Xiang Y.T.
Tan C.H.
Chong M.Y.
Park Y.C.
Kato T.A.
Shinfuku N.
Baldessarini R.J.
Sim K.
Chew Q.H.
Lin S.K.
Yang S.Y.
Ouyang W.C.
Chen C.K.
Park S.C.
Jang O.J.
Park J.H.
Chee K.Y.
Ding K.S.
Chong J.
Zhang L.
Li K.
Zhu X.
Jatchavala C.
Pariwatcharakul P.
Kallivayalil R.A.
Grover S.
Avasthi A.
Ansari M.
Maramis M.M.
Aung P.P.
Sartorius N.
Xiang Y.T.
Tan C.H.
Chong M.Y.
Park Y.C.
Kato T.A.
Shinfuku N.
Baldessarini R.J.
Sim K.
Author's Affiliation
Pushpagiri Institute of Medical Sciences and Research Centre
Chang Gung University School of Medicine
Siriraj Hospital
Graduate School of Medical Sciences
The Affiliated Guangji Hospital of Soochow University
Jeju National University Hospital
Beijing Anding Hospital, Capital Medical University
Hanyang University Guri Hospital
University of Yangon
Universitas Airlangga
Liaquat University of Medical and Health Sciences
Chang Gung Memorial Hospital
Hanyang University College of Medicine
Taipei City Hospital Taiwan
Kuala Lumpur Hospital
Faculty of Medicine, Prince of Songkia University
University of Macau
Seinan Gakuin University
National University of Singapore
McLean Hospital
Kementerian Kesihatan Malaysia
Kaohsiung Medical University
Singapore Institute of Mental Health
Harvard Medical School
Postgraduate Institute of Medical Education & Research, Chandigarh
Hebei Provincical Mental Health Center Baoding
Shu-Zen Junior College of Medicine and Management
Association for the Improvement of Mental Health Programmes
Hospital Bahagia Ulu Kinta
Jianan Psychiatric Center
Bugok National Hospital
Chang Gung University School of Medicine
Siriraj Hospital
Graduate School of Medical Sciences
The Affiliated Guangji Hospital of Soochow University
Jeju National University Hospital
Beijing Anding Hospital, Capital Medical University
Hanyang University Guri Hospital
University of Yangon
Universitas Airlangga
Liaquat University of Medical and Health Sciences
Chang Gung Memorial Hospital
Hanyang University College of Medicine
Taipei City Hospital Taiwan
Kuala Lumpur Hospital
Faculty of Medicine, Prince of Songkia University
University of Macau
Seinan Gakuin University
National University of Singapore
McLean Hospital
Kementerian Kesihatan Malaysia
Kaohsiung Medical University
Singapore Institute of Mental Health
Harvard Medical School
Postgraduate Institute of Medical Education & Research, Chandigarh
Hebei Provincical Mental Health Center Baoding
Shu-Zen Junior College of Medicine and Management
Association for the Improvement of Mental Health Programmes
Hospital Bahagia Ulu Kinta
Jianan Psychiatric Center
Bugok National Hospital
Other Contributor(s)
Abstract
Background Because use and dosing of mood stabilizers (MSs) to treat bipolar disorder (BD) patients in Asia are not well documented, we examined prevalence and clinical correlates of treatment of Asian BD patients with relatively high doses of MSs. Methods We conducted a pharmacoepidemiological survey across 13 Asian countries and territory in the Research on Asian Psychotropic Prescription Patterns Consortium. Mood stabilizer doses were converted to lithium carbonate equivalents (Li-eq milligrams per day). We compared relatively high (>900 Li-eq mg/day) versus lower MS doses by bivariate comparisons, followed by multivariable linear regression to identify factors associated with higher MS doses. Results Among 1647 participants, MS dose averaged 584 (confidence interval, 565-603 Li-eq mg/d). Preliminarily, the 13.1% of the subjects given greater than 900 mg/d versus those given lower doses were younger, male, currently hospitalized, not currently depressed, and reported lifetime suicidal ideation; they also received relatively high doses of antipsychotics, received electroconvulsive treatment within the previous 12 months, and had greater ratings of tremors and sedation. By linear regression modeling, the mean proportion given high doses of MS was associated significantly and independently with higher doses of antipsychotics, younger age, male sex, hospitalized, more years of illness, country, higher body mass index, recent electroconvulsive treatment, and being in illness remission. Conclusions Relatively high doses of MSs for BD are prevalent, but vary markedly among Asian countries, and are particularly likely among young males, ill for many years, and given high doses of antipsychotics or ECT. These characteristics allow better identification of patient profiles that can guide treatment of BD patients.