Surface coating of orthopedic implant to enhance the osseointegration and reduction of bacterial colonization: a review
Issued Date
2022-12-01
Resource Type
eISSN
20557124
Scopus ID
2-s2.0-85132169708
Journal Title
Biomaterials Research
Volume
26
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Biomaterials Research Vol.26 No.1 (2022)
Suggested Citation
Bohara S., Suthakorn J. Surface coating of orthopedic implant to enhance the osseointegration and reduction of bacterial colonization: a review. Biomaterials Research Vol.26 No.1 (2022). doi:10.1186/s40824-022-00269-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85072
Title
Surface coating of orthopedic implant to enhance the osseointegration and reduction of bacterial colonization: a review
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
The use of orthopedic implants in surgical technology has fostered restoration of physiological functions. Along with successful treatment, orthopedic implants suffer from various complications and fail to offer functions correspondent to native physiology. The major problems include aseptic and septic loosening due to bone nonunion and implant site infection due to bacterial colonization. Crucial advances in material selection in the design and development of coating matrixes an opportunity for the prevention of implant failure. However, many coating materials are limited in in-vitro testing and few of them thrive in clinical tests. The rate of implant failure has surged with the increasing rates of revision surgery creating physical and sensitive discomfort as well as economic burdens. To overcome critical pathogenic activities several systematic coating techniques have been developed offering excellent results that combat infection and enhance bone integration. This review article includes some more common implant coating matrixes with excellent in vitro and in vivo results focusing on infection rates, causes, complications, coating materials, host immune responses and significant research gaps. This study provides a comprehensive overview of potential coating technology, with functional combination coatings which are focused on ultimate clinical practice with substantial improvement on in-vivo tests. This includes the development of rapidly growing hydrogel coating techniques with the potential to generate several accurate and precise coating procedures.