Factors Predicting Health-related Quality of Life Among People With Epilepsy

Abstract

Background: Epilepsy is a chronic neurological disease that has a significant influence on individuals' daily activities and health-related quality of life (HRQoL). The HRQoL among people with epilepsy varies depending on several factors. This study aimed to investigate the HRQoL of people with epilepsy and its predicting factors. Methods: A convenience sampling method was applied to enroll 157 participants with epilepsy who were treated with medication at a tertiary hospital in Bangkok, Thailand, from August 2023 to January 2024. The questionnaires included general characteristics, comorbidities, generalized anxiety disorder (GAD), the International Physical Activity Questionnaire (IPAQ) short form, the Pittsburgh Sleep Quality Index (PSQI), the Medical Outcomes Study Social Support Survey (MOS-SSS) and quality of life in epilepsy inventory-31 (QOLIE-31). Descriptive statistics and multiple regression analysis were used to analyze data. Results: The average age of participants was 39.9 years (SD ¼ 10.7), with 51 % being male. 31.8 % of them still experienced a seizure within the last month. The mean total HRQoL score was 74.6 (SD ¼ 13.9). Comorbidities (B ¼ ¡17.50), anxiety (B ¼ ¡1.58), seizure frequency in the last month (B ¼ ¡0.67), and social support score (B ¼ 0.10) were significant predictors of total HRQoL among adults with epilepsy (p-values <0.05), accounting for 50.3 % of the explained variation. Conclusions: Healthcare providers should regularly assess HRQoL and its significant factors among people with epilepsy. Proper management and comprehensive care should be provided to improve the quality of life of people with epilepsy.