Association of zinc deficiency with infectious complications in pediatric hematopoietic stem cell transplantation patients
Issued Date
2022-12-01
Resource Type
eISSN
19326203
Scopus ID
2-s2.0-85144635617
Pubmed ID
36574381
Journal Title
PLoS ONE
Volume
17
Issue
12 December
Rights Holder(s)
SCOPUS
Bibliographic Citation
PLoS ONE Vol.17 No.12 December (2022)
Suggested Citation
Suwanphoerung W., Klinmalai C., Rattanasiri S., Pakakasama S., Anurathapan U., Hongeng S., Chongviriyaphan N., Apiwattanakul N. Association of zinc deficiency with infectious complications in pediatric hematopoietic stem cell transplantation patients. PLoS ONE Vol.17 No.12 December (2022). doi:10.1371/journal.pone.0279439 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86358
Title
Association of zinc deficiency with infectious complications in pediatric hematopoietic stem cell transplantation patients
Author's Affiliation
Other Contributor(s)
Abstract
Background Zinc plays essential roles in immune function and epithelial integrity. Patients undergoing hematopoietic stem cell transplantation (HSCT) often have low plasma zinc levels because of poor intake and diarrhea. We hypothesized that patients with zinc deficiency before HSCT had worse infectious complications after HSCT compared with patients with normal zinc levels. Citrulline, a marker of intestinal integrity, was also hypothesized to be lower in patients with zinc deficiency. Patients and methods Thirty patients undergoing HSCT at Ramathibodi Hospital during March 2020–Septem-ber 2021 were enrolled. Blood samples for plasma zinc and citrulline were collected during the HSCT period. The 14- and 90-day outcomes after HSCT were prospectively recorded. Results Twelve of 30 (40%) patients had zinc deficiency before HSCT. Zinc-deficient patients were younger (median (interquartile range): 6 (8.8) vs 13 (5.8) years old; p = 0.017). Zinc levels tended to increase after admission in both groups. Patients with zinc deficiency had lower citrulline levels than those with normal zinc levels. Citrulline levels decreased in both groups after stem cell infusion, and the level was not significantly different between the two groups. Zinc-deficient patients had a higher rate of bacterial infection within 90 days after HSCT than those with normal zinc levels (6 in 12 patients (50.0%) vs 1 in 18 patients (5.6%); odds ratio [OR]: 17.0; 95% confidence interval [CI]: 1.68–171.70; p = 0.016). This remained significant after adjustments for age (adjusted OR: 12.31; 95% CI: 1.084–139.92; p = 0.043). Conclusion The prevalence of zinc deficiency in pediatric patients undergoing HSCT was high. Zinc-deficient patients had lower citrulline levels and higher incidence of bacterial infection after HSCT. However, citrulline level was not different between patients with and without bacterial infections. It is worth to investigate whether zinc supplementation before HSCT can reduce bacterial infection after HSCT.