Immunogenicity of SARS-CoV-2 vaccines in patients with multiple myeloma: a systematic review and meta-analysis
Issued Date
2022-12-27
Resource Type
ISSN
24739529
eISSN
24739537
Scopus ID
2-s2.0-85147587083
Pubmed ID
36538342
Journal Title
Blood Advances
Volume
6
Issue
24
Start Page
6198
End Page
6207
Rights Holder(s)
SCOPUS
Bibliographic Citation
Blood Advances Vol.6 No.24 (2022) , 6198-6207
Suggested Citation
Chuleerarux N., Manothummetha K., Moonla C., Sanguankeo A., Kates O.S., Hirankarn N., Phongkhun K., Thanakitcharu J., Leksuwankun S., Meejun T., Thongkam A., Mongkolkaew T., Dioverti M.V., Torvorapanit P., Langsiri N., Worasilchai N., Plongla R., Chindamporn A., Gopinath S., Nissaisorakarn P., Thaniyavarn T., Nematollahi S., Permpalung N. Immunogenicity of SARS-CoV-2 vaccines in patients with multiple myeloma: a systematic review and meta-analysis. Blood Advances Vol.6 No.24 (2022) , 6198-6207. 6207. doi:10.1182/bloodadvances.2022008530 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/87148
Title
Immunogenicity of SARS-CoV-2 vaccines in patients with multiple myeloma: a systematic review and meta-analysis
Author(s)
Chuleerarux N.
Manothummetha K.
Moonla C.
Sanguankeo A.
Kates O.S.
Hirankarn N.
Phongkhun K.
Thanakitcharu J.
Leksuwankun S.
Meejun T.
Thongkam A.
Mongkolkaew T.
Dioverti M.V.
Torvorapanit P.
Langsiri N.
Worasilchai N.
Plongla R.
Chindamporn A.
Gopinath S.
Nissaisorakarn P.
Thaniyavarn T.
Nematollahi S.
Permpalung N.
Manothummetha K.
Moonla C.
Sanguankeo A.
Kates O.S.
Hirankarn N.
Phongkhun K.
Thanakitcharu J.
Leksuwankun S.
Meejun T.
Thongkam A.
Mongkolkaew T.
Dioverti M.V.
Torvorapanit P.
Langsiri N.
Worasilchai N.
Plongla R.
Chindamporn A.
Gopinath S.
Nissaisorakarn P.
Thaniyavarn T.
Nematollahi S.
Permpalung N.
Author's Affiliation
Siriraj Hospital
VA Boston Healthcare System
Faculty of Medicine, Chiang Mai University
Massachusetts General Hospital
Chulalongkorn University
King Chulalongkorn Memorial Hospital
University of Miami Leonard M. Miller School of Medicine
University of Arizona College of Medicine – Tucson
Brigham and Women's Hospital
Faculty of Medicine, Srinakharinwirot University
Faculty of Medicine, Chulalongkorn University
Johns Hopkins School of Medicine
VA Boston Healthcare System
Faculty of Medicine, Chiang Mai University
Massachusetts General Hospital
Chulalongkorn University
King Chulalongkorn Memorial Hospital
University of Miami Leonard M. Miller School of Medicine
University of Arizona College of Medicine – Tucson
Brigham and Women's Hospital
Faculty of Medicine, Srinakharinwirot University
Faculty of Medicine, Chulalongkorn University
Johns Hopkins School of Medicine
Other Contributor(s)
Abstract
Patients with multiple myeloma (MM) have a diminished immune response to coronavirus disease 2019 (COVID-19) vaccines. Risk factors for an impaired immune response are yet to be determined. We aimed to summarize the COVID-19 vaccine immunogenicity and to identify factors that influence the humoral immune response in patients with MM. Two reviewers independently conducted a literature search in MEDLINE, Embase, ISI Web of Science, Cochrane library, and Clinicaltrials.gov from existence until 24 May 24 2022. (PROSPERO: CRD42021277005). A total of 15 studies were included in the systematic review and 5 were included in the meta-analysis. The average rate (range) of positive functional T-lymphocyte response was 44.2% (34.2%-48.5%) after 2 doses of messenger RNA (mRNA) COVID-19 vaccines. The average antispike antibody response rates (range) were 42.7% (20.8%-88.5%) and 78.2% (55.8%-94.2%) after 1 and 2 doses of mRNA COVID-19 vaccines, respectively. The average neutralizing antibody response rates (range) were 25% (1 study) and 62.7% (53.3%-68.6%) after 1 and 2 doses of mRNA COVID-19 vaccines, respectively. Patients with high-risk cytogenetics or receiving anti-CD38 therapy were less likely to have a humoral immune response with pooled odds ratios of 0.36 (95% confidence interval [95% CI], 0.18, 0.69), I2 = 0% and 0.42 (95% CI, 0.22, 0.79), I2 = 14%, respectively. Patients who were not on active MM treatment were more likely to respond with pooled odds ratio of 2.42 (95% CI, 1.10, 5.33), I2 = 7%. Patients with MM had low rates of humoral and cellular immune responses to the mRNA COVID-19 vaccines. Further studies are needed to determine the optimal doses of vaccines and evaluate the use of monoclonal antibodies for pre-exposure prophylaxis in this population.