The natural history of childhood-onset nonallergic rhinitis; a long-term follow-up study
1
Issued Date
2025-06-01
Resource Type
ISSN
0125877X
Scopus ID
2-s2.0-105011257569
Pubmed ID
37061935
Journal Title
Asian Pacific Journal of Allergy and Immunology
Volume
43
Issue
2
Start Page
168
End Page
177
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology Vol.43 No.2 (2025) , 168-177
Suggested Citation
Kanchanapoomi K., Srisuwatchari W., Pacharn P., Visitsunthorn N., Jirapongsananuruk O. The natural history of childhood-onset nonallergic rhinitis; a long-term follow-up study. Asian Pacific Journal of Allergy and Immunology Vol.43 No.2 (2025) , 168-177. 177. doi:10.12932/AP-140922-1455 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/111417
Title
The natural history of childhood-onset nonallergic rhinitis; a long-term follow-up study
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Abstract
BACKGROUND: Non-allergic rhinitis (NAR) is characterized by symptoms of nasal inflammation without allergic sensitization. The long-term outcome of NAR in children is poorly defined. OBJECTIVE: To determine the natural history of childhood-onset NAR and the development of allergic rhinitis (AR) in these children. METHODS: NAR patients who were followed for more than 10 years were evaluated at 3-5 years (E2) and 9-12 years (E3) after the first evaluation (E1). Nasal symptoms, disease severity, comorbidities, medication used, and aeroallergen sensitization were assessed. RESULTS: Eighty-two NAR patients (58.5% male) completed all 3 evaluations. The age at onset was 2.0 (range 2.0-4.0) years. The follow-up period was 13.6 (range 12.3-14.3) years. At E2, 37.8% of patients developed AR. At E3, the patients were classified into four groups based on results of skin prick tests in E2 and E3 (group I: NAR→NAR→NAR, 39.0%, group II: NAR→NAR→AR, 23.2%, group III: NAR→AR→NAR, 12.2% and group IV: NAR→AR→AR, 25.6%). The most common aeroallergen sensitization was house dust mite. The family history of atopy, asthma and allergic rhinitis were higher in group III and IV than other groups (p < 0.05). The atopic dermatitis, obstructive sleep apnea and adenotonsillar hypertrophy at E1 and E2 were predominantly found in group IV (p < 0.05). At E2, group III and IV patients had higher proportion of exposure to house dust, animal dander and smoking compared to other groups (p < 0.05). The overall remission rate was 14.6%. CONCLUSIONS: Children with NAR should be reevaluated periodically to determine aeroallergen sensitization for the appropriate diagnosis and management.