Cytotoxic Isopimarane Diterpenoids from Kaempferia koratensis Rhizomes
Issued Date
2023-04-01
Resource Type
eISSN
1981528X
Scopus ID
2-s2.0-85147287988
Journal Title
Revista Brasileira de Farmacognosia
Volume
33
Issue
2
Start Page
415
End Page
421
Rights Holder(s)
SCOPUS
Bibliographic Citation
Revista Brasileira de Farmacognosia Vol.33 No.2 (2023) , 415-421
Suggested Citation
Kongwaen P., Boonsombat J., Thongnest S., Ruchisansakun S., Mahidol C., Ruchirawat S. Cytotoxic Isopimarane Diterpenoids from Kaempferia koratensis Rhizomes. Revista Brasileira de Farmacognosia Vol.33 No.2 (2023) , 415-421. 421. doi:10.1007/s43450-023-00359-w Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82846
Title
Cytotoxic Isopimarane Diterpenoids from Kaempferia koratensis Rhizomes
Other Contributor(s)
Abstract
Two new isopimarane diterpenoids, koratanes A and B, were identified from the rhizomes of Kaempferia koratensis Picheans., Zingiberaceae, together with thirteen known isopimarane diterpenoids. Spectroscopic evidence was used to determine the structures. CD spectra were applied to determine the absolute configuration of koratanes A. The isolated compounds were evaluated for their cytotoxicity against human HL-60 and MOLT-3 leukemia cells, T-47D breast cancer cells, and MRC-5 healthy cells. Among the isolates, compounds named koratanes A, koratanes B, boesenberrol J, saraburane B, kaempulchraol A, kaempulchraol B, kaempulchraol C, and curcumrinol A showed IC50 values ranging from 42.10 to 56.57 μM against MOLT-3 cancer cell line. Koratanes B and galangol D were the most active against HL-60 and T-47D with IC50 values of 55.62 and 79.51 μM, respectively. Graphical Abstract: [Figure not available: see fulltext.].