Physical stability of Pickering nanoemulsions stabilized with chitosan-octenyl succinic anhydride-modified starch polyelectrolyte complex
Issued Date
2022-01-01
Resource Type
eISSN
26300087
Scopus ID
2-s2.0-85148289707
Journal Title
Science, Engineering and Health Studies
Volume
16
Rights Holder(s)
SCOPUS
Bibliographic Citation
Science, Engineering and Health Studies Vol.16 (2022)
Suggested Citation
Sodalee K., Puttipipatkhachorn S. Physical stability of Pickering nanoemulsions stabilized with chitosan-octenyl succinic anhydride-modified starch polyelectrolyte complex. Science, Engineering and Health Studies Vol.16 (2022). doi:10.14456/sehs.2022.28 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86631
Title
Physical stability of Pickering nanoemulsions stabilized with chitosan-octenyl succinic anhydride-modified starch polyelectrolyte complex
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
This study aimed to investigate the effect of various parameters, including the molar charge ratio of chitosan-OSA-modified starch, starch-to-oil ratio, and preparation methods on the physical stability of Pickering nanoemulsions stabilized with chitosan-octenyl succinic anhydride (OSA)-modified starch polyelectrolyte complex (PEC). The nanoemulsions were prepared via ultrasonication using two different methods, namely, the PEC and layer-by-layer (LBL) methods. The investigated physical properties included appearance, droplet size, size distribution, and zeta potential of the nanoemulsions. The results indicated that at a molar charge ratio of 10:1, the nanoemulsions with chitosan-OSA-modified starch PECs had better physical stability. The droplet size, size distribution, and zeta potential were not statistically changed after 4 weeks of storage at 30 ± 2°C. At a lower chitosan-OSA-modified starch ratio, the LBL method provided better physically stable nanoemulsions than the PEC method. However, at a higher chitosan-OSA-modified starch ratio, both methods gave the nanoemulsions with comparable stability. The higher physical stability was attributable to the PEC of chitosan with OSA-modified starch at the o/w interface. In conclusion, the Pickering nanoemulsions stabilized with chitosan-OSA-modified starch PECs are a promising emulsion template for the encapsulation of lipophilic drugs.
