Antimicrobial resistance patterns in bacteria causing febrile illness in Africa, South Asia, and Southeast Asia: a systematic review of published etiological studies from 1980-2015
Issued Date
2022-09-01
Resource Type
ISSN
12019712
eISSN
18783511
Scopus ID
2-s2.0-85134764441
Pubmed ID
35817284
Journal Title
International Journal of Infectious Diseases
Volume
122
Start Page
612
End Page
621
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Infectious Diseases Vol.122 (2022) , 612-621
Suggested Citation
Roberts T., Dahal P., Shrestha P., Schilling W., Shrestha R., Ngu R., Huong V.T.L., van Doorn H.R., Phimolsarnnousith V., Miliya T., Crump J.A., Bell D., Newton P.N., Dittrich S., Hopkins H., Stepniewska K., Guerin P.J., Ashley E.A., Turner P. Antimicrobial resistance patterns in bacteria causing febrile illness in Africa, South Asia, and Southeast Asia: a systematic review of published etiological studies from 1980-2015. International Journal of Infectious Diseases Vol.122 (2022) , 612-621. 621. doi:10.1016/j.ijid.2022.07.018 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/85593
Title
Antimicrobial resistance patterns in bacteria causing febrile illness in Africa, South Asia, and Southeast Asia: a systematic review of published etiological studies from 1980-2015
Author's Affiliation
Angkor Hospital for Children
Faculty of Tropical Medicine, Mahidol University
Oxford University Clinical Research Unit
Foundation for Innovative New Diagnostics, Switzerland
Otago Medical School
London School of Hygiene & Tropical Medicine
University of Oxford
Mahosot Hospital, Lao
Nuffield Department of Medicine
Independent Consultant
Faculty of Tropical Medicine, Mahidol University
Oxford University Clinical Research Unit
Foundation for Innovative New Diagnostics, Switzerland
Otago Medical School
London School of Hygiene & Tropical Medicine
University of Oxford
Mahosot Hospital, Lao
Nuffield Department of Medicine
Independent Consultant
Other Contributor(s)
Abstract
Objective: In this study, we aimed to conduct a systematic review to characterize antimicrobial resistance (AMR) patterns for bacterial causes of febrile illness in Africa and Asia. Methods: We included published literature from 1980-2015 based on data extracted from two recent systematic reviews of nonmalarial febrile illness from Africa, South Asia, and Southeast Asia. Selection criteria included articles with full bacterial identification and antimicrobial susceptibility testing (AST) results for key normally sterile site pathogen-drug combinations. Pooled proportions of resistant isolates were combined using random effects meta-analysis. Study data quality was graded using the Microbiology Investigation Criteria for Reporting Objectively (MICRO) framework. Results: Of 3475 unique articles included in the previous reviews, 371 included the target pathogen-drug combinations. Salmonella enterica tested against ceftriaxone and ciprofloxacin were the two highest reported combinations (30,509 and 22,056 isolates, respectively). Pooled proportions of resistant isolates were high for third-generation cephalosporins for Klebsiella pneumoniae and Escherichia coli in all regions. The MICRO grading showed an overall lack of standardization. Conclusion: This review highlights a general increase in AMR reporting and in resistance over time. However, there were substantial problems with diagnostic microbiological data quality. Urgent strengthening of laboratory capacity, standardized testing, and reporting of AST results is required to improve AMR surveillance.