Emerging Role of the Mast Cell–Microbiota Crosstalk in Cutaneous Homeostasis and Immunity
Issued Date
2023-11-01
Resource Type
eISSN
20734409
Scopus ID
2-s2.0-85177646680
Journal Title
Cells
Volume
12
Issue
22
Rights Holder(s)
SCOPUS
Bibliographic Citation
Cells Vol.12 No.22 (2023)
Suggested Citation
Bosveld C.J., Guth C., Limjunyawong N., Pundir P. Emerging Role of the Mast Cell–Microbiota Crosstalk in Cutaneous Homeostasis and Immunity. Cells Vol.12 No.22 (2023). doi:10.3390/cells12222624 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91267
Title
Emerging Role of the Mast Cell–Microbiota Crosstalk in Cutaneous Homeostasis and Immunity
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
The skin presents a multifaceted microbiome, a balanced coexistence of bacteria, fungi, and viruses. These resident microorganisms are fundamental in upholding skin health by both countering detrimental pathogens and working in tandem with the skin’s immunity. Disruptions in this balance, known as dysbiosis, can lead to disorders like psoriasis and atopic dermatitis. Central to the skin’s defense system are mast cells. These are strategically positioned within the skin layers, primed for rapid response to any potential foreign threats. Recent investigations have started to unravel the complex interplay between these mast cells and the diverse entities within the skin’s microbiome. This relationship, especially during times of both balance and imbalance, is proving to be more integral to skin health than previously recognized. In this review, we illuminate the latest findings on the ties between mast cells and commensal skin microorganisms, shedding light on their combined effects on skin health and maladies.