MAdCAM-1 costimulation in the presence of retinoic acid and TGF-β promotes HIV infection and differentiation of CD4+ T cells into CCR5+ TRM -like cells
Issued Date
2023-03-01
Resource Type
ISSN
15537366
eISSN
15537374
Scopus ID
2-s2.0-85151043923
Pubmed ID
36897929
Journal Title
PLoS Pathogens
Volume
19
Issue
3
Rights Holder(s)
SCOPUS
Bibliographic Citation
PLoS Pathogens Vol.19 No.3 (2023)
Suggested Citation
Vimonpatranon S., Goes L.R., Chan A., Licavoli I., McMurry J., Wertz S.R., Arakelyan A., Huang D., Jiang A., Huang C., Zhou J., Yolitz J., Girard A., Van Ryk D., Wei D., Hwang I.Y., Martens C., Kanakabandi K., Virtaneva K., Ricklefs S., Darwitz B.P., Soares M.A., Pattanapanyasat K., Fauci A.S., Arthos J., Cicala C. MAdCAM-1 costimulation in the presence of retinoic acid and TGF-β promotes HIV infection and differentiation of CD4+ T cells into CCR5+ TRM -like cells. PLoS Pathogens Vol.19 No.3 (2023). doi:10.1371/journal.ppat.1011209 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/81632
Title
MAdCAM-1 costimulation in the presence of retinoic acid and TGF-β promotes HIV infection and differentiation of CD4+ T cells into CCR5+ TRM -like cells
Author(s)
Author's Affiliation
Siriraj Hospital
NIAID Rocky Mountain Laboratories
St. Bonaventure University
National Institute of Child Health and Human Development (NICHD)
National Institute of Allergy and Infectious Diseases (NIAID)
Instituto Nacional de Cancer
National Cancer Institute (NCI)
Universidade Federal do Rio de Janeiro
Georgiamune
NIAID Rocky Mountain Laboratories
St. Bonaventure University
National Institute of Child Health and Human Development (NICHD)
National Institute of Allergy and Infectious Diseases (NIAID)
Instituto Nacional de Cancer
National Cancer Institute (NCI)
Universidade Federal do Rio de Janeiro
Georgiamune
Other Contributor(s)
Abstract
CD4+ tissue resident memory T cells (TRMs) are implicated in the formation of persistent HIV reservoirs that are established during the very early stages of infection. The tissue-specific factors that direct T cells to establish tissue residency are not well defined, nor are the factors that establish viral latency. We report that costimulation via MAdCAM-1 and retinoic acid (RA), two constituents of gut tissues, together with TGF-β, promote the differentiation of CD4+ T cells into a distinct subset α4β7 +CD69+CD103+ TRM -like cells. Among the costimulatory ligands we evaluated, MAdCAM-1 was unique in its capacity to upregulate both CCR5 and CCR9. MAdCAM-1 costimulation rendered cells susceptible to HIV infection. Differentiation of TRM -like cells was reduced by MAdCAM-1 antagonists developed to treat inflammatory bowel diseases. These finding provide a framework to better understand the contribution of CD4+ TRMs to persistent viral reservoirs and HIV pathogenesis.