Interplay between key metabolic hormones, metabolic factors, renal function, and heart rate variability in humans with obesity
Issued Date
2025-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-105020294826
Journal Title
Scientific Reports
Volume
15
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.15 No.1 (2025)
Suggested Citation
Pongwattanapakin K., Care C., Sitticharoon C., Wilasrusmee K.T., Keadkraichaiwat I., Maikaew P., Sririwichitchai R. Interplay between key metabolic hormones, metabolic factors, renal function, and heart rate variability in humans with obesity. Scientific Reports Vol.15 No.1 (2025). doi:10.1038/s41598-025-21757-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/112923
Title
Interplay between key metabolic hormones, metabolic factors, renal function, and heart rate variability in humans with obesity
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Corresponding Author(s)
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Abstract
This study aimed to provide the first integrative assessment of clinical, metabolic, renal, hormonal, and heart rate variability (HRV) parameters in individuals with obesity, stratified by metabolic syndrome (MetS) and insulin resistance (IR), clarifying shared and distinct mechanisms beyond prior HRV- or hormone-focused studies. Among 45 participants with obesity (BMI ≥ 25 kg/m²), 67% had IR and 42% had MetS. Both groups exhibited increased %fat, triglyceride, leptin, and resting heart rate, with decreased QUICKI and high-density lipoprotein cholesterol (HDL-C) (p < 0.05 all). Frequency-domain HRV (VLF and LF ms²) and overall variability (SDNN) were significantly decreased in the IR group (p < 0.05 all). Leptin showed significant positive correlations with obesity, IR, and creatinine clearance (p < 0.05 all). Adiponectin exhibited positive correlations with hip circumference, HDL-C, and pNN50 while HDL-C showed negative correlations with the number of MetS criteria, obesity, IR, and leptin, but positive correlations with parasympathetic HRV (SDSD and RMSSD) (p < 0.05 all), suggesting a protective role across multiple systems. Creatinine clearance and eGFR revealed positive correlations with parasympathetic HRV (HF nu) and negative correlations with sympathetic HRV (LF nu and LF/HF ratio). In conclusion, this study underscores the complex interplay between these systems, enhancing our understanding of their shared and distinct mechanisms.