Characterization of children with IgE-mediated wheat allergy and risk factors that predict wheat anaphylaxis
Issued Date
2022-09-01
Resource Type
ISSN
0125877X
eISSN
22288694
Scopus ID
2-s2.0-85136341512
Pubmed ID
32247307
Journal Title
Asian Pacific Journal of Allergy and Immunology
Volume
40
Issue
3
Start Page
263
End Page
268
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Pacific Journal of Allergy and Immunology Vol.40 No.3 (2022) , 263-268
Suggested Citation
Srisuwatchari W., Vichyanond P., Jirapongsananuruk O., Visitsunthorn N., Pacharn P. Characterization of children with IgE-mediated wheat allergy and risk factors that predict wheat anaphylaxis. Asian Pacific Journal of Allergy and Immunology Vol.40 No.3 (2022) , 263-268. 268. doi:10.12932/ap-130919-0645 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/84919
Title
Characterization of children with IgE-mediated wheat allergy and risk factors that predict wheat anaphylaxis
Author's Affiliation
Other Contributor(s)
Abstract
Background: The number of children presenting with IgE-mediated wheat reactions to academic medical centers in Thailand continues to increase. Objective: Improved knowledge about the clinical characteristic of wheat allergy is urgently needed to better understand the risk factors and to improve proper treatment in this patient population. Methods: A cross-sectional study using questionnaire review of children who presented with IgE-mediated wheat allergy during 2001 to 2015 was performed. Patients were divided into the wheat anaphylaxis (WA) or the only skin symptoms (SO) group. Results: One hundred children were enrolled. Fifty-one and 49 patients were allocated to the WA and SO group, respectively. The median age was 40.5 months (range: 6-200), and the median age of onset was 7 months (range: 3-96). The vast majority (90%) developed their first reaction after their first ingestion of wheat. Atopic dermatitis (AD) was found to be the only significant difference between groups and found more commonly in SO than in WA (59.2% vs. 35.3%, p = 0.02). Median mean wheal diameter (MWD) of skin prick test (SPT) and median sIgE level to wheat were higher in WA than in SO (8 vs. 3 mm, p < 0.001; and, 33.3 vs. 3.6 kUA /l, p < 0.001). Conclusion: Children with wheat allergy presented very early in life. AD was found in approximately half of the patients, and more commonly in SO. Median MWD of SPT and sIgE level to wheat were significantly higher in WA. These data will aid in further planning for a larger survey and intervention study in wheat allergy.