Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019
Issued Date
2022-03-01
Resource Type
ISSN
22138587
eISSN
22138595
Scopus ID
2-s2.0-85124883929
Pubmed ID
35143780
Journal Title
The Lancet Diabetes and Endocrinology
Volume
10
Issue
3
Start Page
177
End Page
192
Rights Holder(s)
SCOPUS
Bibliographic Citation
The Lancet Diabetes and Endocrinology Vol.10 No.3 (2022) , 177-192
Suggested Citation
Cousin E., Duncan B.B., Stein C., Ong K.L., Vos T., Abbafati C., Abbasi-Kangevari M., Abdelmasseh M., Abdoli A., Abd-Rabu R., Abolhassani H., Abu-Gharbieh E., Accrombessi M.M.K., Adnani Q.E.S., Afzal M.S., Agarwal G., Agrawaal K.K., Agudelo-Botero M., Ahinkorah B.O., Ahmad S., Ahmad T., Ahmadi K., Ahmadi S., Ahmadi A., Ahmed A., Salih Y.A., Akande-Sholabi W., Akram T., Al Hamad H.A., Al-Aly Z., Alcalde-Rabanal J.E., Alipour V., Aljunid S.M., Al-Raddadi R.M., Alvis-Guzman N., Amini S., Ancuceanu R., Andrei T., Andrei C.L., Anjana R.M., Ansar A., Antonazzo I.C., Antony B., Anyasodor A.E., Arabloo J., Arizmendi D., Armocida B., Artamonov A.A., Arulappan J., Aryan Z., Asgari S., Ashraf T., Astell-Burt T., Atorkey P., Atout M.M.d.W., Ayanore M.A., Badiye A.D., Baig A.A., Bairwa M., Baker J.L., Baltatu O.C., Banik P.C., Barnett A., Barone M.T.U., Barone-Adesi F., Barrow A., Bedi N., Belete R., Belgaumi U.I., Bell A.W., Bennett D.A., Bensenor I.M., Beran D., Bhagavathula A.S., Bhaskar S., Bhattacharyya K., Bhojaraja V.S., Bijani A., Bikbov B., Birara S., Bodolica V., Bonny A., Brenner H., Briko N.I., Butt Z.A., Caetano dos Santos F.L., Cámera L.A., Campos-Nonato I.R., Cao Y., Cao C., Cerin E., Chakraborty P.A., Chandan J.S., Chattu V.K., Chen S., Jee-Young Jasmine Choi, Choudhari S.G., Chowdhury E.K., Chu D.T., Corso B. Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019. The Lancet Diabetes and Endocrinology Vol.10 No.3 (2022) , 177-192. 192. doi:10.1016/S2213-8587(21)00349-1 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/90235
Title
Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019
Author(s)
Cousin E.
Duncan B.B.
Stein C.
Ong K.L.
Vos T.
Abbafati C.
Abbasi-Kangevari M.
Abdelmasseh M.
Abdoli A.
Abd-Rabu R.
Abolhassani H.
Abu-Gharbieh E.
Accrombessi M.M.K.
Adnani Q.E.S.
Afzal M.S.
Agarwal G.
Agrawaal K.K.
Agudelo-Botero M.
Ahinkorah B.O.
Ahmad S.
Ahmad T.
Ahmadi K.
Ahmadi S.
Ahmadi A.
Ahmed A.
Salih Y.A.
Akande-Sholabi W.
Akram T.
Al Hamad H.A.
Al-Aly Z.
Alcalde-Rabanal J.E.
Alipour V.
Aljunid S.M.
Al-Raddadi R.M.
Alvis-Guzman N.
Amini S.
Ancuceanu R.
Andrei T.
Andrei C.L.
Anjana R.M.
Ansar A.
Antonazzo I.C.
Antony B.
Anyasodor A.E.
Arabloo J.
Arizmendi D.
Armocida B.
Artamonov A.A.
Arulappan J.
Aryan Z.
Asgari S.
Ashraf T.
Astell-Burt T.
Atorkey P.
Atout M.M.d.W.
Ayanore M.A.
Badiye A.D.
Baig A.A.
Bairwa M.
Baker J.L.
Baltatu O.C.
Banik P.C.
Barnett A.
Barone M.T.U.
Barone-Adesi F.
Barrow A.
Bedi N.
Belete R.
Belgaumi U.I.
Bell A.W.
Bennett D.A.
Bensenor I.M.
Beran D.
Bhagavathula A.S.
Bhaskar S.
Bhattacharyya K.
Bhojaraja V.S.
Bijani A.
Bikbov B.
Birara S.
Bodolica V.
Bonny A.
Brenner H.
Briko N.I.
Butt Z.A.
Caetano dos Santos F.L.
Cámera L.A.
Campos-Nonato I.R.
Cao Y.
Cao C.
Cerin E.
Chakraborty P.A.
Chandan J.S.
Chattu V.K.
Chen S.
Jee-Young Jasmine Choi
Choudhari S.G.
Chowdhury E.K.
Chu D.T.
Corso B.
Duncan B.B.
Stein C.
Ong K.L.
Vos T.
Abbafati C.
Abbasi-Kangevari M.
Abdelmasseh M.
Abdoli A.
Abd-Rabu R.
Abolhassani H.
Abu-Gharbieh E.
Accrombessi M.M.K.
Adnani Q.E.S.
Afzal M.S.
Agarwal G.
Agrawaal K.K.
Agudelo-Botero M.
Ahinkorah B.O.
Ahmad S.
Ahmad T.
Ahmadi K.
Ahmadi S.
Ahmadi A.
Ahmed A.
Salih Y.A.
Akande-Sholabi W.
Akram T.
Al Hamad H.A.
Al-Aly Z.
Alcalde-Rabanal J.E.
Alipour V.
Aljunid S.M.
Al-Raddadi R.M.
Alvis-Guzman N.
Amini S.
Ancuceanu R.
Andrei T.
Andrei C.L.
Anjana R.M.
Ansar A.
Antonazzo I.C.
Antony B.
Anyasodor A.E.
Arabloo J.
Arizmendi D.
Armocida B.
Artamonov A.A.
Arulappan J.
Aryan Z.
Asgari S.
Ashraf T.
Astell-Burt T.
Atorkey P.
Atout M.M.d.W.
Ayanore M.A.
Badiye A.D.
Baig A.A.
Bairwa M.
Baker J.L.
Baltatu O.C.
Banik P.C.
Barnett A.
Barone M.T.U.
Barone-Adesi F.
Barrow A.
Bedi N.
Belete R.
Belgaumi U.I.
Bell A.W.
Bennett D.A.
Bensenor I.M.
Beran D.
Bhagavathula A.S.
Bhaskar S.
Bhattacharyya K.
Bhojaraja V.S.
Bijani A.
Bikbov B.
Birara S.
Bodolica V.
Bonny A.
Brenner H.
Briko N.I.
Butt Z.A.
Caetano dos Santos F.L.
Cámera L.A.
Campos-Nonato I.R.
Cao Y.
Cao C.
Cerin E.
Chakraborty P.A.
Chandan J.S.
Chattu V.K.
Chen S.
Jee-Young Jasmine Choi
Choudhari S.G.
Chowdhury E.K.
Chu D.T.
Corso B.
Author's Affiliation
School of Business Administration
School of Medicine and Public Health
Al-Shifa Trust Eye Hospital
Lincoln Medical School
IUMS Health Management and Economics Research Center
Research Center for Immunodeficiencies
Non-Communicable Diseases Research Center
University of The Gambia
Sulaimani Polytechnic University
University of Health and Allied Sciences, Ghana
Institute of Forensic Science, Nagpur
Khomein University of Medical Sciences
Saveetha Medical College and Hospital
Prevention of Metabolic Disorders Research Center
Department of Basic Medical Sciences
Samara University, Ethiopia
Bucharest University of Economic Studies
Universidad de la Costa
Bangladesh University of Health Sciences
Krishna Institute of Medical Sciences Deemed University
Khalifa University of Science and Technology
Universiti Sultan Zainal Abidin
The University of Hong Kong Li Ka Shing Faculty of Medicine
Datta Meghe Institute of Higher Education & Research (Deemed to be University)
Institute for Health Metrics and Evaluation
The Faculty of Health Sciences
Jahrom University of Medical Sciences
Rumailah Hospital
Hamad Medical Corporation
Tribhuvan University
Sultan Qaboos University
Haramaya University
University of Douala
University of Sharjah
University of Management and Technology Lahore
University of Lahore
Universitas Padjadjaran
Centre Hospitalier Intercommunal Le Raincy - Montfermeil
Quaid-i-Azam University
Universidad de Cartagena
Philadelphia University
Kuwait University
Universitatea de Medicina si Farmacie Carol Davila din Bucuresti
Universidad Nacional Autónoma de México
Sapienza Università di Roma
McMaster University
IRCCS Burlo Garofolo
London School of Hygiene & Tropical Medicine
D Y Patil University, Navi Mumbai
Istituto di Ricerche Farmacologiche Mario Negri
University of Washington School of Medicine
Ecole Polytechnique Fédérale de Lausanne
Menzies Institute for Medical Research
Babol University of Medical Sciences
Bispebjerg Hospital
Institute of Neuroscience, Pisa
Universidad Autónoma del Estado de Morelos
Iran University of Medical Sciences
University of Calcutta
University of Technology Sydney
U.S. Department of Veterans Affairs
Washington University School of Medicine in St. Louis
Instituto Nacional de Salud Pública. México
Russian Academy of Sciences
Seoul National University Hospital
Hunter New England NSW Health
University of Birmingham
Monash University
Karolinska Universitetssjukhuset
Shahid Beheshti University of Medical Sciences
Monash University Malaysia
German Cancer Research Center
Universität Heidelberg
University of Toronto
Charles University
University of Waterloo
Università degli Studi di Milano-Bicocca
University of Wollongong
Faculty of Medicine and Health
Australian Catholic University
The University of British Columbia
Washington University in St. Louis
Sechenov First Moscow State Medical University
Harvard University
All India Institute of Medical Sciences, New Delhi
Universidade Anhembi Morumbi
United Arab Emirates University
Instituto Universitario del Hospital Italiano de Buenos Aires
Universidade de São Paulo
La Trobe University
Universidade Federal do Rio Grande do Sul
University of Ibadan
Mayo Clinic
Southeast University
Marshall University
Université de Genève
King Abdulaziz University
Università degli Studi del Piemonte Orientale "Amedeo Avogadro"
University of Oxford Medical Sciences Division
Universiti Kebangsaan Malaysia
Tufts Medical Center
Charles Sturt University
Universiti Sains Malaysia
Madras Diabetes Research Foundation
Partnerships
South West Sydney Local Heath District and Liverpool Hospital
Ministry of Health
Clinical Research Institute of Benin (IRCB)
NSW Brain Clot Bank
Abasyn University
Public Health Association of Australia
Centre for Health Policy Advocacy Innovation & Research in Africa (CHPAIR-Africa)
International University - VNU HCMC
National Institute of Biomedical Genomics
Argentine Society of Medicine
International Diabetes Federation
School of Medicine and Public Health
Al-Shifa Trust Eye Hospital
Lincoln Medical School
IUMS Health Management and Economics Research Center
Research Center for Immunodeficiencies
Non-Communicable Diseases Research Center
University of The Gambia
Sulaimani Polytechnic University
University of Health and Allied Sciences, Ghana
Institute of Forensic Science, Nagpur
Khomein University of Medical Sciences
Saveetha Medical College and Hospital
Prevention of Metabolic Disorders Research Center
Department of Basic Medical Sciences
Samara University, Ethiopia
Bucharest University of Economic Studies
Universidad de la Costa
Bangladesh University of Health Sciences
Krishna Institute of Medical Sciences Deemed University
Khalifa University of Science and Technology
Universiti Sultan Zainal Abidin
The University of Hong Kong Li Ka Shing Faculty of Medicine
Datta Meghe Institute of Higher Education & Research (Deemed to be University)
Institute for Health Metrics and Evaluation
The Faculty of Health Sciences
Jahrom University of Medical Sciences
Rumailah Hospital
Hamad Medical Corporation
Tribhuvan University
Sultan Qaboos University
Haramaya University
University of Douala
University of Sharjah
University of Management and Technology Lahore
University of Lahore
Universitas Padjadjaran
Centre Hospitalier Intercommunal Le Raincy - Montfermeil
Quaid-i-Azam University
Universidad de Cartagena
Philadelphia University
Kuwait University
Universitatea de Medicina si Farmacie Carol Davila din Bucuresti
Universidad Nacional Autónoma de México
Sapienza Università di Roma
McMaster University
IRCCS Burlo Garofolo
London School of Hygiene & Tropical Medicine
D Y Patil University, Navi Mumbai
Istituto di Ricerche Farmacologiche Mario Negri
University of Washington School of Medicine
Ecole Polytechnique Fédérale de Lausanne
Menzies Institute for Medical Research
Babol University of Medical Sciences
Bispebjerg Hospital
Institute of Neuroscience, Pisa
Universidad Autónoma del Estado de Morelos
Iran University of Medical Sciences
University of Calcutta
University of Technology Sydney
U.S. Department of Veterans Affairs
Washington University School of Medicine in St. Louis
Instituto Nacional de Salud Pública. México
Russian Academy of Sciences
Seoul National University Hospital
Hunter New England NSW Health
University of Birmingham
Monash University
Karolinska Universitetssjukhuset
Shahid Beheshti University of Medical Sciences
Monash University Malaysia
German Cancer Research Center
Universität Heidelberg
University of Toronto
Charles University
University of Waterloo
Università degli Studi di Milano-Bicocca
University of Wollongong
Faculty of Medicine and Health
Australian Catholic University
The University of British Columbia
Washington University in St. Louis
Sechenov First Moscow State Medical University
Harvard University
All India Institute of Medical Sciences, New Delhi
Universidade Anhembi Morumbi
United Arab Emirates University
Instituto Universitario del Hospital Italiano de Buenos Aires
Universidade de São Paulo
La Trobe University
Universidade Federal do Rio Grande do Sul
University of Ibadan
Mayo Clinic
Southeast University
Marshall University
Université de Genève
King Abdulaziz University
Università degli Studi del Piemonte Orientale "Amedeo Avogadro"
University of Oxford Medical Sciences Division
Universiti Kebangsaan Malaysia
Tufts Medical Center
Charles Sturt University
Universiti Sains Malaysia
Madras Diabetes Research Foundation
Partnerships
South West Sydney Local Heath District and Liverpool Hospital
Ministry of Health
Clinical Research Institute of Benin (IRCB)
NSW Brain Clot Bank
Abasyn University
Public Health Association of Australia
Centre for Health Policy Advocacy Innovation & Research in Africa (CHPAIR-Africa)
International University - VNU HCMC
National Institute of Biomedical Genomics
Argentine Society of Medicine
International Diabetes Federation
Other Contributor(s)
Abstract
Background: Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods: We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990–2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals. Findings: In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73·7% (68·3 to 77·4) were classified as due to type 1 diabetes. The age-standardised death rate was 0·50 (0·44 to 0·58) per 100 000 population, and 15 900 (97·5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0·13 (0·12 to 0·14) per 100 000 population in the high SDI quintile, 0·60 (0·51 to 0·70) per 100 000 population in the low-middle SDI quintile, and 0·71 (0·60 to 0·86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r2=0·62). From 1990 to 2019, age-standardised death rates decreased globally by 17·0% (−28·4 to −2·9) for all diabetes, and by 21·0% (–33·0 to −5·9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (−13·6% [–28·4 to 3·4]) and for type 1 diabetes (−13·6% [–29·3 to 8·9]). Interpretation: Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN's Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations. Funding: Bill & Melinda Gates Foundation.