The Association Between Central Venous Pressure and Acute Kidney Injury Development in Patients with Septic Shock †
1
Issued Date
2025-05-01
Resource Type
eISSN
20770383
Scopus ID
2-s2.0-105004892870
Journal Title
Journal of Clinical Medicine
Volume
14
Issue
9
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Clinical Medicine Vol.14 No.9 (2025)
Suggested Citation
Nikravangolsefid N., Ninan J., Suppadungsuk S., Singh W., Kashani K.B. The Association Between Central Venous Pressure and Acute Kidney Injury Development in Patients with Septic Shock †. Journal of Clinical Medicine Vol.14 No.9 (2025). doi:10.3390/jcm14093027 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110257
Title
The Association Between Central Venous Pressure and Acute Kidney Injury Development in Patients with Septic Shock †
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Sepsis-associated acute kidney injury (AKI) is linked to increased mortality and prolonged hospital stays. The exact relationship between central venous pressure (CVP) and AKI remains unclear. We explored the correlation between CVP and AKI in septic shock patients. Methods: This retrospective study included adult patients with septic shock admitted to Mayo Clinic Rochester between 2006 and 2018. CVP levels were measured at 6, 12, 24, and 48 h after the diagnosis of sepsis, and patients were stratified into two groups based on CVP levels (CVP < 8 or ≥8 mmHg). Results: Of 5600 patients with septic shock, 3128 patients without AKI on admission are included. One-thousand-and-ninety-eight patients (35.1%) developed AKI within a median of 4.4 days. The median CVP levels and frequency of elevated CVP at 6, 12, 24, and 48 h are significantly higher in the AKI group. Elevated CVP (≥8 mmHg) at 6, 12, 24, and 48 h is associated with AKI incidence, even after adjusting for mean arterial pressure (MAP) levels. This association, after multivariable adjustments, only remains significant at 12 h with an odds ratio (OR) of 1.60 (95% CI, 1.26–2.05), p < 0.001 and 48 h with an OR of 1.60 (95% CI, 1.29–1.99), p < 0.001. Conclusions: Our findings indicate that CVP ≥ 8 mmHg is strongly associated with an increased risk of AKI, even after adjusting for MAP at the 12 and 48 h time points. These findings underscore a critical 12 or 48h window for interventions to lower CVP.