Asia Pacific association of gastroenterology consensus statements on histopathological evaluation of inflammatory bowel diseases
Issued Date
2025-08-01
Resource Type
ISSN
1756283X
eISSN
17562848
Scopus ID
2-s2.0-105024544163
Journal Title
Therapeutic Advances in Gastroenterology
Volume
18
Rights Holder(s)
SCOPUS
Bibliographic Citation
Therapeutic Advances in Gastroenterology Vol.18 (2025)
Suggested Citation
Leong R.W., Chaemsupaphan T., Lin H., Chian Lim W., Ooi C.J., Chetwood J.D., Mao R., Wu H.Y., Wei S.C., Makharia G., Ahuja V., Banerjee R., Atreya R., Limsrivilai J., Aniwan S., Pisespongsa P., Hilmi I., Raja Ali R.A., Leung W.K., Ng S.C., Ye B.D., Kobayashi T., Matsuoka K., Chau C., Sanpavat A., Shun C.T., Puspanathan P., Gearry R.B., Danese S., Ma C., Pudipeddi A., Paramsothy S. Asia Pacific association of gastroenterology consensus statements on histopathological evaluation of inflammatory bowel diseases. Therapeutic Advances in Gastroenterology Vol.18 (2025). doi:10.1177/17562848251363703 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/113596
Title
Asia Pacific association of gastroenterology consensus statements on histopathological evaluation of inflammatory bowel diseases
Author(s)
Leong R.W.
Chaemsupaphan T.
Lin H.
Chian Lim W.
Ooi C.J.
Chetwood J.D.
Mao R.
Wu H.Y.
Wei S.C.
Makharia G.
Ahuja V.
Banerjee R.
Atreya R.
Limsrivilai J.
Aniwan S.
Pisespongsa P.
Hilmi I.
Raja Ali R.A.
Leung W.K.
Ng S.C.
Ye B.D.
Kobayashi T.
Matsuoka K.
Chau C.
Sanpavat A.
Shun C.T.
Puspanathan P.
Gearry R.B.
Danese S.
Ma C.
Pudipeddi A.
Paramsothy S.
Chaemsupaphan T.
Lin H.
Chian Lim W.
Ooi C.J.
Chetwood J.D.
Mao R.
Wu H.Y.
Wei S.C.
Makharia G.
Ahuja V.
Banerjee R.
Atreya R.
Limsrivilai J.
Aniwan S.
Pisespongsa P.
Hilmi I.
Raja Ali R.A.
Leung W.K.
Ng S.C.
Ye B.D.
Kobayashi T.
Matsuoka K.
Chau C.
Sanpavat A.
Shun C.T.
Puspanathan P.
Gearry R.B.
Danese S.
Ma C.
Pudipeddi A.
Paramsothy S.
Author's Affiliation
Chinese University of Hong Kong
Universiti Malaya
Macquarie University
All India Institute of Medical Sciences, New Delhi
National Taiwan University Hospital
Faculty of Medicine and Health
Asan Medical Center
Cumming School of Medicine
Universitätsklinikum Erlangen
Duke-NUS Medical School
The University of Hong Kong Li Ka Shing Faculty of Medicine
Siriraj Hospital
The First Affiliated Hospital, Sun Yat-sen University
University of Otago, Christchurch
Tan Tock Seng Hospital
Humanitas University
Sunway University
Concord Repatriation General Hospital
Faculty of Medicine, Chulalongkorn University
Toho University Medical Center Sakura Hospital
Kitasato University Kitasato Institute Hospital
Asian Institute of Gastroenterology India
Hospital Pulau Pinang
Bumrungrad International Hospital
Universiti Malaya
Macquarie University
All India Institute of Medical Sciences, New Delhi
National Taiwan University Hospital
Faculty of Medicine and Health
Asan Medical Center
Cumming School of Medicine
Universitätsklinikum Erlangen
Duke-NUS Medical School
The University of Hong Kong Li Ka Shing Faculty of Medicine
Siriraj Hospital
The First Affiliated Hospital, Sun Yat-sen University
University of Otago, Christchurch
Tan Tock Seng Hospital
Humanitas University
Sunway University
Concord Repatriation General Hospital
Faculty of Medicine, Chulalongkorn University
Toho University Medical Center Sakura Hospital
Kitasato University Kitasato Institute Hospital
Asian Institute of Gastroenterology India
Hospital Pulau Pinang
Bumrungrad International Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
Background: Mucosal histological activity is increasingly valued as a treatment endpoint in inflammatory bowel diseases (IBD). In the Asia Pacific region, the utility and acceptability of IBD histology as a treatment endpoint are uncertain due to the heterogeneity of IBD prevalence, resourcing and level of knowledge among practitioners. There is an opportunity to engage clinicians to harmonise histology reporting and collaborate with pathologists in this field. Objectives: We aimed to develop consensus statements through anonymous voting on histological features, processing, reporting and relevance to treatment outcomes in IBD, including ulcerative colitis (UC) and Crohn’s disease (CD). Design: The consensus document was developed through a comprehensive literature review, followed by a deliberation process among experts in the field. Methods: Representatives of the Asia Pacific Association of Gastroenterology, in collaboration with pathologists, voted anonymously in accordance with modified Delphi methodology on statements relevant to IBD and histology. Domains of interest were histological features of UC and CD, relevance to clinical management and the potential utility of artificial intelligence (AI) in grading histological disease severity. Level of evidence and recommendation grade were included in accordance with the National Health and Medical Research Council, Australia guidelines of Australia. Results: Consensus was reached on 37 out of 38 statements concerning definitions, pathology processing and reporting, scoring system and relevance to clinical outcomes. Knowledge gaps were identified with uncertainty over the role of AI. Conclusion: These consensus statements provide recommendations, with specific relevance to the Asia Pacific region, on the role of histology in IBD to harmonise its use. The statements will promote understanding and applicability in research and in the routine management of IBD.