Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma
Issued Date
2023-01-01
Resource Type
ISSN
13085727
eISSN
13085735
Scopus ID
2-s2.0-85177686986
Pubmed ID
35135186
Journal Title
JCRPE Journal of Clinical Research in Pediatric Endocrinology
Volume
15
Issue
4
Start Page
421
End Page
425
Rights Holder(s)
SCOPUS
Bibliographic Citation
JCRPE Journal of Clinical Research in Pediatric Endocrinology Vol.15 No.4 (2023) , 421-425
Suggested Citation
Thi H.N., Manh C.P., Tuan L.T., Thi L.A.L., Thanh N.N., Vilaiyuk S. Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma. JCRPE Journal of Clinical Research in Pediatric Endocrinology Vol.15 No.4 (2023) , 421-425. 425. doi:10.4274/jcrpe.galenos.2022.2021-8-14 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91275
Title
Tumor-induced Osteomalacia in a Boy with Maxillary Ossifying Fibroma
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Tumor-induced osteomalacia (TIO) is a rare, paraneoplastic disorder of hypophosphatemia associated with elevated tumor-produced fibroblast growth factor 23 (FGF23). Maxillofacial tumors are rarely involved in TIO, especially maxillary TIO in children. We present a 14-year-old boy with osteomalacia and high serum levels of FGF23, a hormone associated with decreased phosphate resorption, due to a maxillary tumor. The patient was treated with oral phosphorus and calcitriol, and surgical removal of the tumor was performed. After 21 months follow-up, he was pain free and had returned to full activity. We review the reported pediatric cases of TIO in the maxillofacial and oral region and discuss the management of these patients considering the published evidence.
