Prevalence, clinical characteristics, and outcomes of fatty pancreas disease: an updated systematic review and meta-analysis
Issued Date
2025-02-01
Resource Type
eISSN
14735687
Scopus ID
2-s2.0-85213597346
Pubmed ID
39589806
Journal Title
European journal of gastroenterology & hepatology
Volume
37
Issue
2
Start Page
137
End Page
146
Rights Holder(s)
SCOPUS
Bibliographic Citation
European journal of gastroenterology & hepatology Vol.37 No.2 (2025) , 137-146
Suggested Citation
Souza M., Silva G.P., Junior C.R.O., Amaral M.J.M., Lima L.C.V., Charatcharoenwitthaya P. Prevalence, clinical characteristics, and outcomes of fatty pancreas disease: an updated systematic review and meta-analysis. European journal of gastroenterology & hepatology Vol.37 No.2 (2025) , 137-146. 146. doi:10.1097/MEG.0000000000002893 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/102737
Title
Prevalence, clinical characteristics, and outcomes of fatty pancreas disease: an updated systematic review and meta-analysis
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Corresponding Author(s)
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Abstract
Fatty pancreas disease (FPD) is a condition characterized by diffuse excessive intrapancreatic fat deposition with relevant metabolic implications but often overlooked by healthcare professionals. Our study aims to provide a comprehensive overview of the prevalence, clinical characteristics, and outcomes of FPD. PubMed and Embase databases were searched from inception to 10 April 2024. Pairwise meta-analysis was performed using the DerSimonian-Laird method. Meta-analysis of proportions was conducted using the inverse-variance method with logit transformation. Between-study heterogeneity was examined, with subsequent subgroup and meta-regression analyses, and publication bias was assessed. Eighteen studies with 111 682 individuals were included in this meta-analysis. The overall prevalence of FPD was 21.11% [95% confidence interval (CI): 11.04-36.58]. Diagnostic method influenced FPD prevalence ( P < 0.01), with pooled prevalences of 17.53% (95% CI: 16.20-18.95), 30.05% (95% CI: 24.14-36.70), and 21.23% (95% CI: 8.52-43.88) for MRI, computed tomography, and transabdominal ultrasound, respectively. Patients with FPD were more likely to be older, have higher BMI, male, and have metabolic dysfunction. They also had an increased risk of metabolic syndrome, endocrine-related outcomes (i.e. diabetes and glycemic progression), and exocrine-related outcomes (i.e. acute pancreatitis and pancreatic cancer) compared with those without FPD. This study summarizes the epidemiology of FPD and highlights its clinical and prognostic significance. Increased multidisciplinary collaboration is needed to improve understanding of the disease and raise awareness among healthcare professionals. This study was a priori registered in International Prospective Register of Systematic Reviews (PROSPERO) (CRD42024514116).