The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia
Issued Date
2024-04-15
Resource Type
eISSN
15354970
Scopus ID
2-s2.0-85190754284
Pubmed ID
38240721
Journal Title
American journal of respiratory and critical care medicine
Volume
209
Issue
8
Start Page
973
End Page
986
Rights Holder(s)
SCOPUS
Bibliographic Citation
American journal of respiratory and critical care medicine Vol.209 No.8 (2024) , 973-986
Suggested Citation
Chouchane O., Schuurman A.R., Reijnders T.D.Y., Peters-Sengers H., Butler J.M., Uhel F., Schultz M.J., Bonten M.J., Cremer O.L., Calfee C.S., Matthay M.A., Langley R.J., Alipanah-Lechner N., Kingsmore S.F., Rogers A., van Weeghel M., Vaz F.M., van der Poll T. The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia. American journal of respiratory and critical care medicine Vol.209 No.8 (2024) , 973-986. 986. doi:10.1164/rccm.202308-1321OC Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/98102
Title
The Plasma Lipidomic Landscape in Patients with Sepsis due to Community-acquired Pneumonia
Author's Affiliation
Amsterdam Gastroenterology Endocrinology Metabolism
Mahidol Oxford Tropical Medicine Research Unit
Emma Kinderziekenhuis
University of South Alabama College of Medicine
University Medical Center Utrecht
University of California, San Francisco
AP-HP Assistance Publique - Hopitaux de Paris
CNRS Centre National de la Recherche Scientifique
Rady Children's Hospital
Center for Experimental and Molecular Medicine
Julius Center for Health Sciences and Primary Care
Core Facility Metabolomics
Laboratory of Experimental Intensive Care and Anesthesiology
Division of Infectious Diseases
Division of Pulmonary and Critical Care Medicine
Mahidol Oxford Tropical Medicine Research Unit
Emma Kinderziekenhuis
University of South Alabama College of Medicine
University Medical Center Utrecht
University of California, San Francisco
AP-HP Assistance Publique - Hopitaux de Paris
CNRS Centre National de la Recherche Scientifique
Rady Children's Hospital
Center for Experimental and Molecular Medicine
Julius Center for Health Sciences and Primary Care
Core Facility Metabolomics
Laboratory of Experimental Intensive Care and Anesthesiology
Division of Infectious Diseases
Division of Pulmonary and Critical Care Medicine
Corresponding Author(s)
Other Contributor(s)
Abstract
Rationale: The plasma lipidome has the potential to reflect many facets of the host status during severe infection. Previous work is limited to specific lipid groups or was focused on lipids as prognosticators.Objectives: To map the plasma lipidome during sepsis due to community-acquired pneumonia (CAP) and determine the disease specificity and associations with clinical features.Methods: We analyzed 1,833 lipid species across 33 classes in 169 patients admitted to the ICU with sepsis due to CAP, 51 noninfected ICU patients, and 48 outpatient controls. In a paired analysis, we reanalyzed patients still in the ICU 4 days after admission (n = 82).Measurements and Main Results: A total of 58% of plasma lipids were significantly lower in patients with CAP-attributable sepsis compared with outpatient controls (6% higher, 36% not different). We found strong lipid class-specific associations with disease severity, validated across two external cohorts, and inflammatory biomarkers, in which triacylglycerols, cholesterol esters, and lysophospholipids exhibited the strongest associations. A total of 36% of lipids increased over time, and stratification by survival revealed diverging lipid recovery, which was confirmed in an external cohort; specifically, a 10% increase in cholesterol ester levels was related to a lower odds ratio (0.84; P = 0.006) for 30-day mortality (absolute mortality, 18 of 82). Comparison with noninfected ICU patients delineated a substantial common illness response (57.5%) and a distinct lipidomic signal for patients with CAP-attributable sepsis (37%).Conclusions: Patients with sepsis due to CAP exhibit a time-dependent and partially disease-specific shift in their plasma lipidome that correlates with disease severity and systemic inflammation and is associated with higher mortality.