Human Leukocyte Antigen (HLA) System: Genetics and Association with Bacterial and Viral Infections
Issued Date
2022-01-01
Resource Type
ISSN
23148861
eISSN
23147156
Scopus ID
2-s2.0-85131348118
Pubmed ID
35664353
Journal Title
Journal of Immunology Research
Volume
2022
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Immunology Research Vol.2022 (2022)
Suggested Citation
Medhasi S., Chantratita N. Human Leukocyte Antigen (HLA) System: Genetics and Association with Bacterial and Viral Infections. Journal of Immunology Research Vol.2022 (2022). doi:10.1155/2022/9710376 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/85052
Title
Human Leukocyte Antigen (HLA) System: Genetics and Association with Bacterial and Viral Infections
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
The human leukocyte antigen (HLA) system is one of the most crucial host factors influencing disease progression in bacterial and viral infections. This review provides the basic concepts of the structure and function of HLA molecules in humans. Here, we highlight the main findings on the associations between HLA class I and class II alleles and susceptibility to important infectious diseases such as tuberculosis, leprosy, melioidosis, Staphylococcus aureus infection, human immunodeficiency virus infection, coronavirus disease 2019, hepatitis B, and hepatitis C in populations worldwide. Finally, we discuss challenges in HLA typing to predict disease outcomes in clinical implementation. Evaluation of the impact of HLA variants on the outcome of bacterial and viral infections would improve the understanding of pathogenesis and identify those at risk from infectious diseases in distinct populations and may improve the individual treatment.