Resilience and Beyond the Acute Phase Challenges: Case Series on Prolonged COVID-19 Infection in Immunocompromised Individuals
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Issued Date
2024-01-01
Resource Type
eISSN
11786973
Scopus ID
2-s2.0-85208625578
Journal Title
Infection and Drug Resistance
Volume
17
Start Page
4727
End Page
4732
Rights Holder(s)
SCOPUS
Bibliographic Citation
Infection and Drug Resistance Vol.17 (2024) , 4727-4732
Suggested Citation
Gulapa K., Eksombatchai D., Petnak T., Boonsarngsuk V. Resilience and Beyond the Acute Phase Challenges: Case Series on Prolonged COVID-19 Infection in Immunocompromised Individuals. Infection and Drug Resistance Vol.17 (2024) , 4727-4732. 4732. doi:10.2147/IDR.S479764 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/102065
Title
Resilience and Beyond the Acute Phase Challenges: Case Series on Prolonged COVID-19 Infection in Immunocompromised Individuals
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Author's Affiliation
Corresponding Author(s)
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Abstract
Background: COVID-19 infection is associated with an increased risk of severe illness and adverse outcomes in individuals with immunocompromising conditions. Immunocompromised patients may have difficulty with viral clearance, which can lead to persistent infection and potential relapses in viral replication. Case Presentation: Herein, we present four cases of persistent COVID-19 pneumonia in immunocompromised patients, including those with diffuse large B-cell lymphoma, polyarteritis nodosa, and end-stage renal disease post-kidney transplant. Three patients had previously received rituximab. Notably, all patients in this cohort demonstrated positive anti-receptor binding-domain immunoglobulin G (IgG) and negative anti-nucleocapsid IgG values. Conclusion: Persistent COVID-19 infection should be considered in the differential diagnosis of immunocompromised patients who exhibit ongoing symptoms or lack of improvement in chest X-ray findings following initial COVID-19 treatment. Early recognition, beyond the diagnosis of post-COVID organizing pneumonia, may significantly improve clinical outcomes with timely and appropriate treatment.