Albiflorenes A–L, polyoxygenated cyclohex(a/e)ne diterpene esters from Kaempferia albiflora
Issued Date
2024-12-01
Resource Type
eISSN
20452322
Scopus ID
2-s2.0-85196111033
Journal Title
Scientific Reports
Volume
14
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Scientific Reports Vol.14 No.1 (2024)
Suggested Citation
Booranaseensuntorn P., Boonsombat J., Thongnest S., Batsomboon P., Reuk-Ngam N., Khlaychan P., Ruchisansakun S., Kittakoop P., Techasakul S., Mahidol C., Ruchirawat S. Albiflorenes A–L, polyoxygenated cyclohex(a/e)ne diterpene esters from Kaempferia albiflora. Scientific Reports Vol.14 No.1 (2024). doi:10.1038/s41598-024-64889-6 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/98902
Title
Albiflorenes A–L, polyoxygenated cyclohex(a/e)ne diterpene esters from Kaempferia albiflora
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Abstract
Twelve polyoxygenated cyclohex(a/e)ne diterpene esters, named albiflorenes A–L (1–12), were isolated from the whole plants of Kaempferia albiflora, known as “Prao Mang Mum.” Their structures and relative stereochemistry were determined by extensive spectroscopic analysis. Furthermore, the comparison of experimental electronic circular dichroism (ECD) curves with the curves predicted by TDDFT was used to determine the absolute configurations. Albiflorenes contain polyoxygenated cyclohexane (or cyclohexene) derivatives, which are linked to either isopimarane or abietane diterpene acid units. The discovery marks the first occurrence of a conjugate between polyoxygenated cyclohexane (or cyclohexene) rings and diterpenoids. Among the isolates, albiflorene C specifically exhibited antibacterial activity against Bacillus cereus with MIC and MBC values of 3.13 and 6.25 μg/mL, respectively.
