Therapeutic potential of microalgae-derived natural compounds in diabetic wound healing: A comprehensive review

Abstract

A variety of cell types and chemical systems are known to interact throughout the complex process of wound healing. In addition to being very uncomfortable for patients, wounds that do not heal properly or become chronic can place a heavy burden on society. The creation of novel treatment approaches can expedite the healing process, reduce the societal burden, and improve patient outcomes. Due to advancements in the field of biomedical science, microalgae have significant potential for use in diabetic wound healing and other wound healing applications. This review delves into the physiological process of wound healing, the use of microalgae in wound healing, and a detailed explanation of the wound healing roles of various microalgal originated bioactive compounds including alginate, pigments, fatty acids, proteins, polysaccharides, flavonoids and phenols. The study discusses the efficacy of photosynthetic hydrogels in drugs and oxygen delivery to the wounded area that is crucial for promoting a good healing process, as well as highlights the drawbacks and challenges involved in using microalgae for wound healing. Given the current state of the art in utilizing microalgae for wound care, this review provides new perspectives for further research, along with insightful advice and innovative suggestions for academics engaged in this area.