Influence of Prolonged Whole Egg Supplementation on Insulin-like Growth Factor 1 and Short-Chain Fatty Acids Product: Implications for Human Health and Gut Microbiota
Issued Date
2023-11-16
Resource Type
eISSN
20726643
Scopus ID
2-s2.0-85177786834
Pubmed ID
38004198
Journal Title
Nutrients
Volume
15
Issue
22
Rights Holder(s)
SCOPUS
Bibliographic Citation
Nutrients Vol.15 No.22 (2023)
Suggested Citation
Suta S., Ophakas S., Manosan T., Honwichit O., Charoensiddhi S., Surawit A., Pongkunakorn T., Pumeiam S., Mongkolsucharitkul P., Pinsawas B., Sutheeworapong S., Puangsombat P., Khoomrung S., Mayurasakorn K. Influence of Prolonged Whole Egg Supplementation on Insulin-like Growth Factor 1 and Short-Chain Fatty Acids Product: Implications for Human Health and Gut Microbiota. Nutrients Vol.15 No.22 (2023). doi:10.3390/nu15224804 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/91325
Title
Influence of Prolonged Whole Egg Supplementation on Insulin-like Growth Factor 1 and Short-Chain Fatty Acids Product: Implications for Human Health and Gut Microbiota
Author's Affiliation
Other Contributor(s)
Abstract
The gut microbiota exert a profound influence on human health and metabolism, with microbial metabolites playing a pivotal role in shaping host physiology. This study investigated the impact of prolonged egg supplementation on insulin-like growth factor 1 (IGF-1) and circulating short-chain fatty acids (SCFAs). In a subset of a cluster-randomized trial, participants aged 8-14 years were randomly assigned into three groups: (1) Whole Egg (WE)-consuming 10 additional eggs per week [n = 24], (2) Protein Substitute (PS)-consuming yolk-free egg substitute equivalent to 10 eggs per week [n = 25], and (3) Control Group (C) [n = 26]. At week 35, IGF-1 levels in WE significantly increased (66.6 ± 27.7 ng/mL, p < 0.05) compared to C, with positive SCFA correlations, except acetate. Acetate was stable in WE, increasing in PS and C. Significant propionate differences occurred between WE and PS (14.8 ± 5.6 μmol/L, p = 0.010). WE exhibited notable changes in the relative abundance of the Bifidobacterium and Prevotella genera. Strong positive SCFA correlations were observed with MAT-CR-H4-C10 and Libanicoccus, while Roseburia, Terrisporobacter, Clostridia_UCG-014, and Coprococcus showed negative correlations. In conclusion, whole egg supplementation improves growth factors that may be related to bone formation and growth; it may also promote benefits to gut microbiota but may not affect SCFAs.