Multifunctional roles and pharmacological potential of β-sitosterol: Emerging evidence toward clinical applications
Issued Date
2022-09-25
Resource Type
ISSN
00092797
eISSN
18727786
Scopus ID
2-s2.0-85138125496
Pubmed ID
35995256
Journal Title
Chemico-Biological Interactions
Volume
365
Rights Holder(s)
SCOPUS
Bibliographic Citation
Chemico-Biological Interactions Vol.365 (2022)
Suggested Citation
Khan Z., Nath N., Rauf A., Emran T.B., Mitra S., Islam F., Chandran D., Barua J., Khandaker M.U., Idris A.M., Wilairatana P., Thiruvengadam M. Multifunctional roles and pharmacological potential of β-sitosterol: Emerging evidence toward clinical applications. Chemico-Biological Interactions Vol.365 (2022). doi:10.1016/j.cbi.2022.110117 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/86836
Title
Multifunctional roles and pharmacological potential of β-sitosterol: Emerging evidence toward clinical applications
Author's Affiliation
Faculty of Tropical Medicine, Mahidol University
University of Swabi
Saveetha Dental College And Hospitals
Sunway University
International Islamic University Chittagong
Amrita Vishwa Vidyapeetham
King Khalid University
Daffodil International University
University of Louisiana at Lafayette
University of Dhaka
Konkuk University
BGC Trust University Bangladesh
University of Swabi
Saveetha Dental College And Hospitals
Sunway University
International Islamic University Chittagong
Amrita Vishwa Vidyapeetham
King Khalid University
Daffodil International University
University of Louisiana at Lafayette
University of Dhaka
Konkuk University
BGC Trust University Bangladesh
Other Contributor(s)
Abstract
Currently, available therapeutic medications are both costly as well as not entirely promising in terms of potency. So, new candidates from natural resources are of research interest to find new alternative therapeutics. A well-known combination is a β-sitosterol, a plant-derived nutrient with anticancer properties against breast, prostate, colon, lung, stomach, and leukemia. Studies have shown that β-sitosterol interferes with multiple cell signaling pathways, including cell cycle, apoptosis, proliferation, survival, invasion, angiogenesis, metastasis, anti-inflammatory, anticancer, hepatoprotective, antioxidant, cardioprotective, and antidiabetic effects have been discovered during pharmacological screening without significant toxicity. The pharmacokinetic profile of β-sitosterol has also been extensively investigated. However, a comprehensive review of the pharmacology, phytochemistry and analytical methods of β-sitosterol is desired. Because β-sitosterol is a significant component of most plant materials, humans use it for various reasons, and numerous β-sitosterol-containing products have been commercialized. To offset the low efficacy of β-sitosterol, designing β-sitosterol delivery for “cancer cell-specific” therapy holds great potential. Delivery of β-sitosterol via liposomes is a demonstration that has shown great promise. But further research has not progressed on the drug delivery of β-sitosterol or how it can enhance β-sitosterol mediated anti-inflammatory activity, thus making β-sitosterol an orphan nutraceutical. Therefore, extensive research on β-sitosterol as an anticancer nutraceutical is recommended.