Association between Charlson Comorbidity Index and positive blood cultures at a tertiary-care hospital in Indonesia
Issued Date
2025-06-01
Resource Type
eISSN
27673375
Scopus ID
2-s2.0-105009267674
Journal Title
Plos Global Public Health
Volume
5
Issue
6
Rights Holder(s)
SCOPUS
Bibliographic Citation
Plos Global Public Health Vol.5 No.6 (2025)
Suggested Citation
Tauran P.M., Arif M., Limmathurotsakul D., de Kraker M.E.A., Aiken A.M. Association between Charlson Comorbidity Index and positive blood cultures at a tertiary-care hospital in Indonesia. Plos Global Public Health Vol.5 No.6 (2025). doi:10.1371/journal.pgph.0004749 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/111070
Title
Association between Charlson Comorbidity Index and positive blood cultures at a tertiary-care hospital in Indonesia
Author's Affiliation
London School of Hygiene & Tropical Medicine
Hôpitaux Universitaires de Genève
Organisation Mondiale de la Santé
Nuffield Department of Medicine
Hasanuddin University
Faculty of Tropical Medicine, Mahidol University
Mahidol Oxford Tropical Medicine Research Unit
Dr. Wahidin Sudirohusodo Hospital
Dr Alberth H. Torey Hospital
Hôpitaux Universitaires de Genève
Organisation Mondiale de la Santé
Nuffield Department of Medicine
Hasanuddin University
Faculty of Tropical Medicine, Mahidol University
Mahidol Oxford Tropical Medicine Research Unit
Dr. Wahidin Sudirohusodo Hospital
Dr Alberth H. Torey Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
Blood culture (BC) tests are a scarce resource in low- and middle-income countries (LMICs); therefore, prioritization based on likelihood of positive results might be beneficial. We aimed to determine whether comorbidities in the Charlson Comorbidity Index (CCI) were associated with positive BC tests among patients with suspected hospital-acquired bacteremia. We analysed a retrospective cohort from health records at Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia from 2015-2018. We applied multivariable logistic regression to identify associations between CCI score and the outcome of the first BC taken two calendar days after admission, adjusting for confounders. The primary analysis considered BCs positive for all pathogens. Of 3,875 adult patients who had their first BCs taken two calendar days after hospital admissions, 786 (20.3%) had their first BCs positive for any pathogen. Those included 371 patients who had their first BCs positive for Staphylococcus aureus (n=133; 35.9%), Acinetobacter spp. (n=84; 22.6%), Klebsiella. pneumoniae (n=58; 15.6%), Escherichia coli (n=63; 17.0%) and Pseudomonas aeruginosa (n=33; 8.9%). There was no association between increasing CCI score and positive BC (OR 1.01, 95%CI: 0.96-1.06, p=0.69) after adjustment for age, sex and other potential confounders. There was some indication that antibiotic use prior to BC test acted as an effect modifier between CCI score and positivity of BC (p=0.17). In this single-hospital study, no significant association was observed between CCI score and positive BC taken two calendar days after hospital admission. We suggest that other factors need to be investigated to guide BC testing, and that improving diagnostic and antibiotic stewardship, including increasing resources for BC testing prior to antibiotics among hospitalized patients are needed in LMICs.