Non-spherical drug particle deposition in human airway using computational fluid dynamics and discrete element method
Issued Date
2023-05-25
Resource Type
ISSN
03785173
eISSN
18733476
Scopus ID
2-s2.0-85153794550
Journal Title
International Journal of Pharmaceutics
Volume
639
Rights Holder(s)
SCOPUS
Bibliographic Citation
International Journal of Pharmaceutics Vol.639 (2023)
Suggested Citation
Tanprasert S., Kampeewichean C., Shiratori S., Piemjaiswang R., Chalermsinsuwan B. Non-spherical drug particle deposition in human airway using computational fluid dynamics and discrete element method. International Journal of Pharmaceutics Vol.639 (2023). doi:10.1016/j.ijpharm.2023.122979 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/81407
Title
Non-spherical drug particle deposition in human airway using computational fluid dynamics and discrete element method
Other Contributor(s)
Abstract
Currently, the air pollution and the respiratory disease problems that affect human health are increasing rapidly. Hence, there is attention for trend prediction of the located deposition of inhaled particles. In this study, Weibel's based human airway model (G0-G5) was employed. The computational fluid dynamics and discrete element method (CFD-DEM) simulation was successfully validated by comparison to the previous research studies. The CFD-DEM achieves a better balance between numerical accuracy and computational requirement when comparing with the other methods. Then, the model was used to analyze the non-spherical drug transport with different drug particle sizes, shapes, density, and concentrations. The results found that all the studied factors affected the drug deposition and particle out-mass percentage except the drug concentration. The drug deposition was increased with the increasing of particle size and particle density due to the influence of particle inertia. The Tomahawk-shaped drug deposited easier than the cylindrical drug shape because of the different drag behavior. For the effect of airway geometries, G0 was the maximum deposited zone and G3 was the minimum deposited zone. The boundary layer was found around bifurcation due to the shear force at the wall. Finally, the knowledge can give an essential recommendation for curing patients with pharmaceutical aerosol. The design suggestion of a proper drug delivery device can be summarized.