Transcription machinery of the minimalist: comparative genomic analysis provides insights into the (de)regulated transcription mechanism of microsporidia — fungal-relative parasites
Issued Date
2023-01-01
Resource Type
ISSN
21541264
eISSN
21541272
Scopus ID
2-s2.0-85147760669
Pubmed ID
36757099
Journal Title
Transcription
Rights Holder(s)
SCOPUS
Bibliographic Citation
Transcription (2023)
Suggested Citation
Chanarat S. Transcription machinery of the minimalist: comparative genomic analysis provides insights into the (de)regulated transcription mechanism of microsporidia — fungal-relative parasites. Transcription (2023). doi:10.1080/21541264.2023.2174765 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82329
Title
Transcription machinery of the minimalist: comparative genomic analysis provides insights into the (de)regulated transcription mechanism of microsporidia — fungal-relative parasites
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Abstract
Microsporidia are eukaryotic obligate intracellular parasites closely related to fungi. Co-evolving with infected hosts, microsporidia have highly reduced their genomes and lacked several biological components. As it is beneficial for intracellular parasites like microsporidia to reduce their genome size, it is therefore reasonable to assume that genes encoding multifactorial complex machinery of transcription could be a potential target to be excluded from microsporidian genomes during the reductive evolution. In such a case, an evolutionary dilemma occurs because microsporidia cannot remove all transcription-machinery-encoding genes, products of which are essential for initialthe initial steps of gene expression. Here, I propose that while genes encoding core machinery are conserved, several genes known to function in fine-tune regulation of transcription are absent. This genome compaction strategy may come at the cost of loosely regulated or less controllable transcription. Alternatively, analogous to microsporidian polar tube, the parasites may have specialized factors to regulate their RNA synthesis.