Pharmacogenomics in Asians: Differences and similarities with other human populations
Issued Date
2023-01-01
Resource Type
ISSN
17425255
eISSN
17447607
Scopus ID
2-s2.0-85148511107
Pubmed ID
36755439
Journal Title
Expert Opinion on Drug Metabolism and Toxicology
Volume
19
Issue
1
Start Page
27
End Page
41
Rights Holder(s)
SCOPUS
Bibliographic Citation
Expert Opinion on Drug Metabolism and Toxicology Vol.19 No.1 (2023) , 27-41
Suggested Citation
Biswas M., Jinda P., Sukasem C. Pharmacogenomics in Asians: Differences and similarities with other human populations. Expert Opinion on Drug Metabolism and Toxicology Vol.19 No.1 (2023) , 27-41. 41. doi:10.1080/17425255.2023.2178895 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/82229
Title
Pharmacogenomics in Asians: Differences and similarities with other human populations
Author(s)
Other Contributor(s)
Abstract
Introduction: Various pharmacogenomic (PGx) variants differ widely in different ethnicities. and clinical outcomes associated with these variants may also be substantially varied. Literature was searched in different databases, i.e. PubMed, ScienceDirect, Web of Science, and PharmGKB, from inception to 30 June 2022 for this review. Areas covered: Certain PGx variants were distinctly varied in Asian populations compared to the other human populations, e.g. CYP2C19*2,*3,*17; CYP2C9*2,*3; CYP2D6*4,*5,*10,*41; UGT1A1*6,*28; HLA-B*15:02, HLA-B*15:21, HLA-B*58:01, and HLA-A*31:01. However, certain other variants do not vary greatly between Asian and other ethnicities, e.g. CYP3A5*3; ABCB1, and SLCO1B1*5. As evident in this review, the risk of major adverse cardiovascular events (MACE) was much stronger in Asian patients taking clopidogrel and who inherited the CYP2C19 loss-of-function alleles, e.g. CYP2C19*2 and*3, when compared to the western/Caucasian patients. Additionally, the risk of carbamazepine-induced severe cutaneous adverse drug reactions (SCARs) for the patients inheriting HLA-B*15:02 and HLA-B*15:21 alleles varied significantly between Asian and other ethnicities. In contrast, both Caucasian and Asian patients inheriting the SLCO1B1*5 variant possessed a similar magnitude of muscle toxicity, i.e. myopathy. Expert opinion: Asian countries should take measures toward expanding PGx research, as well as initiatives for the purposes of obtaining clinical benefits from this newly evolving and economically viable treatment model.