Targeting pediatric solid tumors in the new era of RNA therapeutics
Issued Date
2024-08-01
Resource Type
ISSN
10408428
eISSN
18790461
Scopus ID
2-s2.0-85195181505
Journal Title
Critical Reviews in Oncology/Hematology
Volume
200
Rights Holder(s)
SCOPUS
Bibliographic Citation
Critical Reviews in Oncology/Hematology Vol.200 (2024)
Suggested Citation
Chaiyawat P., Sangkhathat S., Chiangjong W., Wongtrakoongate P., Hongeng S., Pruksakorn D., Chutipongtanate S. Targeting pediatric solid tumors in the new era of RNA therapeutics. Critical Reviews in Oncology/Hematology Vol.200 (2024). doi:10.1016/j.critrevonc.2024.104406 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/98705
Title
Targeting pediatric solid tumors in the new era of RNA therapeutics
Corresponding Author(s)
Other Contributor(s)
Abstract
Despite substantial progress in pediatric cancer treatment, poor prognosis remained for patients with recurrent or metastatic disease, given the limitations of approved targeted treatments and immunotherapies. RNA therapeutics offer significant potential for addressing a broad spectrum of diseases, including cancer. Advances in manufacturing and delivery systems are paving the way for the rapid development of therapeutic RNAs for clinical applications. This review summarizes therapeutic RNA classifications and the mechanisms of action, highlighting their potential in manipulating major cancer-related pathways and biological effects. We also focus on the pre-clinical investigation of RNA molecules with efficient delivery systems for their therapeutic potential targeting pediatric solid tumors.