Association of myopia and parapapillary choroidal microvascular density in primary open-angle glaucoma
Issued Date
2025-02-01
Resource Type
eISSN
19326203
Scopus ID
2-s2.0-85218905247
Journal Title
PLoS ONE
Volume
20
Issue
2 February
Rights Holder(s)
SCOPUS
Bibliographic Citation
PLoS ONE Vol.20 No.2 February (2025)
Suggested Citation
Suwan Y., Chansangpetch S., Fard M.A., Pooprasert P., Chalardsakul K., Threetong T., Tipparut S., Saaensupho T., Tantraworasin A., Hojati S., Kafieh R., Danesh H., Petpiroon P., Supakontanasan W. Association of myopia and parapapillary choroidal microvascular density in primary open-angle glaucoma. PLoS ONE Vol.20 No.2 February (2025). doi:10.1371/journal.pone.0317881 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/105535
Title
Association of myopia and parapapillary choroidal microvascular density in primary open-angle glaucoma
Author's Affiliation
Ramathibodi Hospital
Medical Image and Signal Processing Research Center, Isfahan UMS
Farabi Eye Hospital
Faculty of Medicine, Chiang Mai University
Chulalongkorn University
Durham University
Burapha University
Faculty of Medicine, Chulalongkorn University
Chiang Mai University
Shahid Ashrafi Esfahani University
Medical Image and Signal Processing Research Center, Isfahan UMS
Farabi Eye Hospital
Faculty of Medicine, Chiang Mai University
Chulalongkorn University
Durham University
Burapha University
Faculty of Medicine, Chulalongkorn University
Chiang Mai University
Shahid Ashrafi Esfahani University
Corresponding Author(s)
Other Contributor(s)
Abstract
Background/Aims To compare parapapillary choroidal microvascular (PPCMv) densities between myopic eyes with and without glaucoma. Methods In this retrospective study, OCTA images (4.5 × 4.5 mm) were obtained using a commercial spectral-domain OCTA system. PPCMv density was calculated in inner and outer annuli using customized software. Marginal model of generalized estimating equations was established to adjust for confounding factors and intraclass correlations. Results This study included 35 myopic eyes with glaucoma (MG), 96 non-myopic eyes with glaucoma (NMG) matched for visual field mean deviation, 37 myopic eyes without glaucoma (MNG), and 73 control eyes from three tertiary centers. The participant ages were (mean [standard deviation, SD]) 57.43 [11.49], 60.40 [10.07], 52.84 [9.35], and 54.74 [12.07] years. Inner and outer annular PPCMv densities (mean [SD]) decreased in the following order: control (0.15 [0.04] and 0.12 [0.04]), MNG (0.14 [0.08] and 0.12 [0.08]), NMG (0.09 [0.05] and 0.07 [0.04]), and MG (0.09 [0.04] and 0.07 [0.03]). The mean differences in PPCMv density between glaucoma groups (NMG and MG) and the control group (mean difference [95% confidence interval]) were −0.06 (−0.08 to −0.04, P<0.001 for inner whole annular PPCMv density in NMG vs control) and −0.07 (−0.10 to −0.04, P<0.001 for inner whole annular PPCMv density in MG vs control), consistent across all regions of interest (ROIs). No significant interaction was observed between glaucoma and myopia after adjustment for potential confounders (P>0.112). Conclusions Parapapillary choroidal microvascular density attenuation tends to be greater in eyes with glaucoma than in eyes with myopia.