Switchable Site-Selectivite Direct Acetoxylation of Pyrazolones
Issued Date
2025-01-01
Resource Type
eISSN
21935815
Scopus ID
2-s2.0-85217552864
Journal Title
Asian Journal of Organic Chemistry
Rights Holder(s)
SCOPUS
Bibliographic Citation
Asian Journal of Organic Chemistry (2025)
Suggested Citation
Kittikool T., Viriyanukul T., Phakdeeyothin K., Yotphan S. Switchable Site-Selectivite Direct Acetoxylation of Pyrazolones. Asian Journal of Organic Chemistry (2025). doi:10.1002/ajoc.202400808 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/105354
Title
Switchable Site-Selectivite Direct Acetoxylation of Pyrazolones
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Abstract
Site-selective direct acetoxylation of pyrazolones was accomplished by utilizing an easy-to-handle (diacetoxyiodo)benzene (PIDA) as the sole acetoxylating reagent. In the presence of Pd(OAc)2 catalyst, the 4-acetoxylated pyrazolone product was exclusively formed. Meanwhile, in the absence of Pd(OAc)2, the pyrazolone methyl acetate product was obtained over the Csp2−H bond functionalization. Both approaches have been successfully applied to various pyrazolone substrates, giving the corresponding products in moderate to high yields under mild conditions.