Extracellular vesicle therapy in neurological disorders
Issued Date
2024-12-01
Resource Type
ISSN
10217770
eISSN
14230127
Scopus ID
2-s2.0-85201941115
Journal Title
Journal of Biomedical Science
Volume
31
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Biomedical Science Vol.31 No.1 (2024)
Suggested Citation
Putthanbut N., Lee J.Y., Borlongan C.V. Extracellular vesicle therapy in neurological disorders. Journal of Biomedical Science Vol.31 No.1 (2024). doi:10.1186/s12929-024-01075-w Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100652
Title
Extracellular vesicle therapy in neurological disorders
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Abstract
Extracellular vesicles (EVs) are vital for cell-to-cell communication, transferring proteins, lipids, and nucleic acids in various physiological and pathological processes. They play crucial roles in immune modulation and tissue regeneration but are also involved in pathogenic conditions like inflammation and degenerative disorders. EVs have heterogeneous populations and cargo, with numerous subpopulations currently under investigations. EV therapy shows promise in stimulating tissue repair and serving as a drug delivery vehicle, offering advantages over cell therapy, such as ease of engineering and minimal risk of tumorigenesis. However, challenges remain, including inconsistent nomenclature, complex characterization, and underdeveloped large-scale production protocols. This review highlights the recent advances and significance of EVs heterogeneity, emphasizing the need for a better understanding of their roles in disease pathologies to develop tailored EV therapies for clinical applications in neurological disorders. Graphical abstract: (Figure presented.)