HIV treatment outcomes after 10 years on ART in the TREAT Asia Observational Database (TAHOD) and Australian HIV Observational Database (AHOD)
Issued Date
2024-01-01
Resource Type
ISSN
15254135
eISSN
19447884
Scopus ID
2-s2.0-85202664557
Pubmed ID
39169454
Journal Title
Journal of Acquired Immune Deficiency Syndromes
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Acquired Immune Deficiency Syndromes (2024)
Suggested Citation
Jiamsakul A., Rupasinghe D., Woolley I., Choi J.Y., Templeton D.J., Widhani A., Petoumenos K., Tanuma J., Khol V., Zhang F.J., Zhao H.X., Han N., Lee M.P., Li P.C.K., Kwong T.S., Li T.H., Kumarasamy N., Ezhilarasi C., Pujari S., Joshi K., Gaikwad S., Chitalikar A., Sangle S., Mave V., Marbaniang I., Nimkar S., Merati T.P., Wirawan D.N., Yuliana F., Yunihastuti E., Widhani A., Maria S., Karjadi T.H., Tanuma J., Oka S., Nishijima T., Choi J.Y., Na S., Kim J.M., Gani Y.M., Rudi N.B., Azwa I., Kamarulzaman A., Omar S.F.S., Ponnampalavanar S., Ditangco R., Pasayan M.K., Mationg M.L., Chan Y.J., Ku W.W., Wu P.C., Ke E., Ng O.T., Lim P.L., Lee L.S., Yap T., Avihingsanon A., Gatechompol S., Phanuphak P., Phadungphon C., Kiertiburanakul S., Phuphuakrat A., Chumla L., Sanmeema N., Chaiwarith R., Sirisanthana T., Praparattanapan J., Nuket K., Khusuwan S., Kantipong P., Kambua P., Nguyen K.V., Bui H.V., Nguyen D.T.H., Nguyen D.T., Do C.D., Ngo A.V., Nguyen L.T., Sohn A.H., Ross J.L., Petersen B., Law M.G., Jiamsakul A., Rupasinghe D., Ellis D., Bloch M., Winter D., Soma S., Murphy L., Marci S., Coleman I., Burton L., Baker D., Farlow H., Byrne E., Williamson C., Templeton D.J., Garton L., Doyle T., Jackson E. HIV treatment outcomes after 10 years on ART in the TREAT Asia Observational Database (TAHOD) and Australian HIV Observational Database (AHOD). Journal of Acquired Immune Deficiency Syndromes (2024). doi:10.1097/QAI.0000000000003515 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/101111
Title
HIV treatment outcomes after 10 years on ART in the TREAT Asia Observational Database (TAHOD) and Australian HIV Observational Database (AHOD)
Author(s)
Jiamsakul A.
Rupasinghe D.
Woolley I.
Choi J.Y.
Templeton D.J.
Widhani A.
Petoumenos K.
Tanuma J.
Khol V.
Zhang F.J.
Zhao H.X.
Han N.
Lee M.P.
Li P.C.K.
Kwong T.S.
Li T.H.
Kumarasamy N.
Ezhilarasi C.
Pujari S.
Joshi K.
Gaikwad S.
Chitalikar A.
Sangle S.
Mave V.
Marbaniang I.
Nimkar S.
Merati T.P.
Wirawan D.N.
Yuliana F.
Yunihastuti E.
Widhani A.
Maria S.
Karjadi T.H.
Tanuma J.
Oka S.
Nishijima T.
Choi J.Y.
Na S.
Kim J.M.
Gani Y.M.
Rudi N.B.
Azwa I.
Kamarulzaman A.
Omar S.F.S.
Ponnampalavanar S.
Ditangco R.
Pasayan M.K.
Mationg M.L.
Chan Y.J.
Ku W.W.
Wu P.C.
Ke E.
Ng O.T.
Lim P.L.
Lee L.S.
Yap T.
Avihingsanon A.
Gatechompol S.
Phanuphak P.
Phadungphon C.
Kiertiburanakul S.
Phuphuakrat A.
Chumla L.
Sanmeema N.
Chaiwarith R.
Sirisanthana T.
Praparattanapan J.
Nuket K.
Khusuwan S.
Kantipong P.
Kambua P.
Nguyen K.V.
Bui H.V.
Nguyen D.T.H.
Nguyen D.T.
Do C.D.
Ngo A.V.
Nguyen L.T.
Sohn A.H.
Ross J.L.
Petersen B.
Law M.G.
Jiamsakul A.
Rupasinghe D.
Ellis D.
Bloch M.
Winter D.
Soma S.
Murphy L.
Marci S.
Coleman I.
Burton L.
Baker D.
Farlow H.
Byrne E.
Williamson C.
Templeton D.J.
Garton L.
Doyle T.
Jackson E.
Rupasinghe D.
Woolley I.
Choi J.Y.
Templeton D.J.
Widhani A.
Petoumenos K.
Tanuma J.
Khol V.
Zhang F.J.
Zhao H.X.
Han N.
Lee M.P.
Li P.C.K.
Kwong T.S.
Li T.H.
Kumarasamy N.
Ezhilarasi C.
Pujari S.
Joshi K.
Gaikwad S.
Chitalikar A.
Sangle S.
Mave V.
Marbaniang I.
Nimkar S.
Merati T.P.
Wirawan D.N.
Yuliana F.
Yunihastuti E.
Widhani A.
Maria S.
Karjadi T.H.
Tanuma J.
Oka S.
Nishijima T.
Choi J.Y.
Na S.
Kim J.M.
Gani Y.M.
Rudi N.B.
Azwa I.
Kamarulzaman A.
Omar S.F.S.
Ponnampalavanar S.
Ditangco R.
Pasayan M.K.
Mationg M.L.
Chan Y.J.
Ku W.W.
Wu P.C.
Ke E.
Ng O.T.
Lim P.L.
Lee L.S.
Yap T.
Avihingsanon A.
Gatechompol S.
Phanuphak P.
Phadungphon C.
Kiertiburanakul S.
Phuphuakrat A.
Chumla L.
Sanmeema N.
Chaiwarith R.
Sirisanthana T.
Praparattanapan J.
Nuket K.
Khusuwan S.
Kantipong P.
Kambua P.
Nguyen K.V.
Bui H.V.
Nguyen D.T.H.
Nguyen D.T.
Do C.D.
Ngo A.V.
Nguyen L.T.
Sohn A.H.
Ross J.L.
Petersen B.
Law M.G.
Jiamsakul A.
Rupasinghe D.
Ellis D.
Bloch M.
Winter D.
Soma S.
Murphy L.
Marci S.
Coleman I.
Burton L.
Baker D.
Farlow H.
Byrne E.
Williamson C.
Templeton D.J.
Garton L.
Doyle T.
Jackson E.
Author's Affiliation
Sydney Local Health District
Ramathibodi Hospital
Hospital Sungai Buloh
Beijing Ditan Hospital Capital Medical University
VHS Medical Centre India
Research Institute for Tropical Medicine
Bach Mai Hospital
Universitas Udayana
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
Thai Red Cross Agency
UNSW Sydney
The Kirby Institute
National Center for Global Health and Medicine
Monash University
Yonsei University College of Medicine
Queen Elizabeth Hospital Hong Kong
University of Malaya Medical Centre
Taipei Veterans General Hospital
Faculty of Medicine and Health
Tan Tock Seng Hospital
Chiang Mai University
Plaza Medical Centre
HIV Clinic
Holdsworth House Medical Practice
BJ Government Medical College and Sassoon General Hospital
East Sydney Doctors
RPA Sexual Health
Lismore Sexual Health Services
National Hospital for Tropical Diseases
National Center for HIV/AIDS
amfAR - The Foundation for AIDS Research
Institute of Infectious Diseases
Chiangrai Prachanukroh Hospital
Ramathibodi Hospital
Hospital Sungai Buloh
Beijing Ditan Hospital Capital Medical University
VHS Medical Centre India
Research Institute for Tropical Medicine
Bach Mai Hospital
Universitas Udayana
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
Thai Red Cross Agency
UNSW Sydney
The Kirby Institute
National Center for Global Health and Medicine
Monash University
Yonsei University College of Medicine
Queen Elizabeth Hospital Hong Kong
University of Malaya Medical Centre
Taipei Veterans General Hospital
Faculty of Medicine and Health
Tan Tock Seng Hospital
Chiang Mai University
Plaza Medical Centre
HIV Clinic
Holdsworth House Medical Practice
BJ Government Medical College and Sassoon General Hospital
East Sydney Doctors
RPA Sexual Health
Lismore Sexual Health Services
National Hospital for Tropical Diseases
National Center for HIV/AIDS
amfAR - The Foundation for AIDS Research
Institute of Infectious Diseases
Chiangrai Prachanukroh Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
Background Increasing numbers of people with HIV have received prolonged antiretroviral therapy (ART). We assessed long-term immunological and survival outcomes among people with HIV from Asia (TAHOD) and Australia (AHOD). Methods People with HIV receiving ART for ≥10 years were included. Factors associated with CD4 counts in years 11-15 of ART were analysed using repeated measure linear regression. Survival after 10 years was analysed using competing risk regression. Results There were 7139 people included: 4867 (68%) from TAHOD and 2272 (32%) from AHOD. Higher CD4 after 10 years were observed if the nadir CD4 in the first decade was higher (CD4 (cells/μL) 101-200: difference=35, 95%CI 18, 51; >200: difference=125, 95%CI 107, 142) compared to ≤50. The same patterns were observed in those who achieved CD4 ≥500 cells/μL which subsequently decreased to <500 (difference=225, 95%CI 213, 236); or those who achieved and maintained CD4 ≥500 cells/μL (difference=402, 95%CI 384, 420), compared to always <500 in the previous decade. Prior protease inhibitor (PI) -based regimen (difference=-17, 95%CI -33, -1) compared to no PI, and previous treatment interruptions (TI) of 14 days to 3 months and >6 months were associated with lower CD4 counts after 10 years (difference = -38, 95%CI -62, -15; and difference=-44, 95%CI -61, -27, respectively) compared to no TI. The mortality rate was 1.04 per 100 person-years. Virological failure was associated with subsequent mortality (sub-hazard ratio=1.34, 95%CI 1.04, 1.71). Conclusions Sustaining high CD4 levels and minimising TI has far-reaching benefits well beyond the first decade of ART.