Mitochondria-derived vesicles and their potential roles in kidney stone disease
Issued Date
2023-12-01
Resource Type
eISSN
14795876
Scopus ID
2-s2.0-85157976173
Pubmed ID
37131163
Journal Title
Journal of Translational Medicine
Volume
21
Issue
1
Rights Holder(s)
SCOPUS
Bibliographic Citation
Journal of Translational Medicine Vol.21 No.1 (2023)
Suggested Citation
Chaiyarit S., Thongboonkerd V. Mitochondria-derived vesicles and their potential roles in kidney stone disease. Journal of Translational Medicine Vol.21 No.1 (2023). doi:10.1186/s12967-023-04133-3 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/81532
Title
Mitochondria-derived vesicles and their potential roles in kidney stone disease
Author(s)
Author's Affiliation
Other Contributor(s)
Abstract
Recent evidence has shown significant roles of mitochondria-derived vesicles (MDVs) in mitochondrial quality control (MQC) system. Under mild stress condition, MDVs are formed to carry the malfunctioned mitochondrial components, such as mitochondrial DNA (mtDNA), peptides, proteins and lipids, to be eliminated to restore normal mitochondrial structure and functions. Under severe oxidative stress condition, mitochondrial dynamics (fission/fusion) and mitophagy are predominantly activated to rescue mitochondrial structure and functions. Additionally, MDVs generation can be also triggered as the major MQC machinery to cope with unhealthy mitochondria when mitophagy is unsuccessful for eliminating the damaged mitochondria or mitochondrial fission/fusion fail to recover the mitochondrial structure and functions. This review summarizes the current knowledge on MDVs and discuss their roles in physiologic and pathophysiologic conditions. In addition, the potential clinical relevance of MDVs in therapeutics and diagnostics of kidney stone disease (KSD) are emphasized.