Extranodal Marginal Zone Lymphoma Presenting as Acute Kidney Injury due to Cast Nephropathy: A Case Report
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Issued Date
2025-01-01
Resource Type
eISSN
20543581
Scopus ID
2-s2.0-105007522080
Journal Title
Canadian Journal of Kidney Health and Disease
Volume
12
Rights Holder(s)
SCOPUS
Bibliographic Citation
Canadian Journal of Kidney Health and Disease Vol.12 (2025)
Suggested Citation
Naruemon N., Iamsai P., Ounpanyo P., Cheunsuchon B., Vongchaiudomchoke T. Extranodal Marginal Zone Lymphoma Presenting as Acute Kidney Injury due to Cast Nephropathy: A Case Report. Canadian Journal of Kidney Health and Disease Vol.12 (2025). doi:10.1177/20543581251338434 Retrieved from: https://repository.li.mahidol.ac.th/handle/123456789/110729
Title
Extranodal Marginal Zone Lymphoma Presenting as Acute Kidney Injury due to Cast Nephropathy: A Case Report
Author's Affiliation
Corresponding Author(s)
Other Contributor(s)
Abstract
Acute kidney injury (AKI) in non-Hodgkin lymphoma has diverse etiologies. We report a case in which AKI due to light chain cast nephropathy was the initial manifestation of extranodal marginal zone lymphoma, occurring without systemic symptoms. A 64-year-old male presented with severe AKI without other symptoms. His physical examination and renal ultrasound were unremarkable. Renal biopsy revealed light chain cast nephropathy, and a subsequent bone marrow biopsy confirmed marginal zone lymphoma. The patient received R-CHOP chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone) for a total of six cycles. The patient had a partial response to lymphoma. However, his renal function did not improve, and ultimately he progressed to end-stage kidney disease, requiring maintenance hemodialysis. This case highlights extranodal marginal zone lymphoma presenting as AKI, emphasizing its unique renal-limited manifestation in the absence of systemic symptoms and the critical role of renal biopsy in diagnosing unexplained AKI.