Retinoblastoma in Asia: Clinical Presentation and Treatment Outcomes in 2112 Patients from 33 Countries
Issued Date
2023-01-01
Resource Type
ISSN
01616420
eISSN
15494713
Scopus ID
2-s2.0-85184698821
Pubmed ID
37839559
Journal Title
Ophthalmology
Rights Holder(s)
SCOPUS
Bibliographic Citation
Ophthalmology (2023)
Suggested Citation
Kaliki S., Vempuluru V.S., Mohamed A., Al-Jadiry M.F., Bowman R., Chawla B., Hamid S.A., Ji X., Kapelushnik N., Kebudi R., Sthapit P.R., Rojanaporn D., Sitorus R.S., Yousef Y.A., Fabian I.D., Abdulqader R.A., Aggarwal P., Ahmad A., Akib M.N.R., Al Mesfer S.A., Al Ani M.H., Al-Badri S.A.F., Angeles Alcasabas A.P., Al-Dahmash S.A., Al-Haddad C., Yahya Al-Hussaini H.H., Al-Jumaily U., Alkatan H.M., Razzaq Mahmood Al-Mafrachi A.A., Samad Majeed Al-Shaheen A.A., Al-Shammary E.H., Amiruddin P.O., Armytasari I., Astbury N.J., Atalay H.T., Ataseven E., Atchaneeyasakul L.o., Balayeva R., Bascaran C., Begimkulova A.S., Bhaduri A., Bhat S., Bhattacharyya A., Blum S., Buaboonnam J., Burton M.J., Caspi S., Chaudhry S., Chen W., Chuluunbat T., Dangboon W., Das A., Das P., Das S., Du Y., Dudeja G., Eka Sutyawan I.W., Fadoo Z., Faranoush M., Foster A., Frenkel S., Ghassemi F., Gomel N., Gunasekera D.S., Gündüz A.K., Gupta H., Gupta S., Gupta V., Hamzah N., Hasanreisoglu M., Hassan S., Haydar H.A., Hongeng S., Hussein Al-Janabi A.N., Islamov Z., Janjua T.A., Jeeva I., Jo D.H., Kantar M., Keomisy J., Khan Z.J., Khaqan H.A., Khetan V., Khodabande A., Kim J.H., Kiratli H., Koç I., Kulvichit K., Kuntorini M.W., Li C., Li K., Limbu B., Liu C.H., Lutfi D., Mahajan A., Maitra P., Makimbetov E.K., Maktabi A.M.Y., Manzhuova L., Masud S. Retinoblastoma in Asia: Clinical Presentation and Treatment Outcomes in 2112 Patients from 33 Countries. Ophthalmology (2023). doi:10.1016/j.ophtha.2023.10.015 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/97274
Title
Retinoblastoma in Asia: Clinical Presentation and Treatment Outcomes in 2112 Patients from 33 Countries
Author(s)
Kaliki S.
Vempuluru V.S.
Mohamed A.
Al-Jadiry M.F.
Bowman R.
Chawla B.
Hamid S.A.
Ji X.
Kapelushnik N.
Kebudi R.
Sthapit P.R.
Rojanaporn D.
Sitorus R.S.
Yousef Y.A.
Fabian I.D.
Abdulqader R.A.
Aggarwal P.
Ahmad A.
Akib M.N.R.
Al Mesfer S.A.
Al Ani M.H.
Al-Badri S.A.F.
Angeles Alcasabas A.P.
Al-Dahmash S.A.
Al-Haddad C.
Yahya Al-Hussaini H.H.
Al-Jumaily U.
Alkatan H.M.
Razzaq Mahmood Al-Mafrachi A.A.
Samad Majeed Al-Shaheen A.A.
Al-Shammary E.H.
Amiruddin P.O.
Armytasari I.
Astbury N.J.
Atalay H.T.
Ataseven E.
Atchaneeyasakul L.o.
Balayeva R.
Bascaran C.
Begimkulova A.S.
Bhaduri A.
Bhat S.
Bhattacharyya A.
Blum S.
Buaboonnam J.
Burton M.J.
Caspi S.
Chaudhry S.
Chen W.
Chuluunbat T.
Dangboon W.
Das A.
Das P.
Das S.
Du Y.
Dudeja G.
Eka Sutyawan I.W.
Fadoo Z.
Faranoush M.
Foster A.
Frenkel S.
Ghassemi F.
Gomel N.
Gunasekera D.S.
Gündüz A.K.
Gupta H.
Gupta S.
Gupta V.
Hamzah N.
Hasanreisoglu M.
Hassan S.
Haydar H.A.
Hongeng S.
Hussein Al-Janabi A.N.
Islamov Z.
Janjua T.A.
Jeeva I.
Jo D.H.
Kantar M.
Keomisy J.
Khan Z.J.
Khaqan H.A.
Khetan V.
Khodabande A.
Kim J.H.
Kiratli H.
Koç I.
Kulvichit K.
Kuntorini M.W.
Li C.
Li K.
Limbu B.
Liu C.H.
Lutfi D.
Mahajan A.
Maitra P.
Makimbetov E.K.
Maktabi A.M.Y.
Manzhuova L.
Masud S.
Vempuluru V.S.
Mohamed A.
Al-Jadiry M.F.
Bowman R.
Chawla B.
Hamid S.A.
Ji X.
Kapelushnik N.
Kebudi R.
Sthapit P.R.
Rojanaporn D.
Sitorus R.S.
Yousef Y.A.
Fabian I.D.
Abdulqader R.A.
Aggarwal P.
Ahmad A.
Akib M.N.R.
Al Mesfer S.A.
Al Ani M.H.
Al-Badri S.A.F.
Angeles Alcasabas A.P.
Al-Dahmash S.A.
Al-Haddad C.
Yahya Al-Hussaini H.H.
Al-Jumaily U.
Alkatan H.M.
Razzaq Mahmood Al-Mafrachi A.A.
Samad Majeed Al-Shaheen A.A.
Al-Shammary E.H.
Amiruddin P.O.
Armytasari I.
Astbury N.J.
Atalay H.T.
Ataseven E.
Atchaneeyasakul L.o.
Balayeva R.
Bascaran C.
Begimkulova A.S.
Bhaduri A.
Bhat S.
Bhattacharyya A.
Blum S.
Buaboonnam J.
Burton M.J.
Caspi S.
Chaudhry S.
Chen W.
Chuluunbat T.
Dangboon W.
Das A.
Das P.
Das S.
Du Y.
Dudeja G.
Eka Sutyawan I.W.
Fadoo Z.
Faranoush M.
Foster A.
Frenkel S.
Ghassemi F.
Gomel N.
Gunasekera D.S.
Gündüz A.K.
Gupta H.
Gupta S.
Gupta V.
Hamzah N.
Hasanreisoglu M.
Hassan S.
Haydar H.A.
Hongeng S.
Hussein Al-Janabi A.N.
Islamov Z.
Janjua T.A.
Jeeva I.
Jo D.H.
Kantar M.
Keomisy J.
Khan Z.J.
Khaqan H.A.
Khetan V.
Khodabande A.
Kim J.H.
Kiratli H.
Koç I.
Kulvichit K.
Kuntorini M.W.
Li C.
Li K.
Limbu B.
Liu C.H.
Lutfi D.
Mahajan A.
Maitra P.
Makimbetov E.K.
Maktabi A.M.Y.
Manzhuova L.
Masud S.
Author's Affiliation
Lahore General Hospital
National University of Medical Sciences
Narayana Health
Ramathibodi Hospital
Siriraj Hospital
Tilganga Institute of Ophthalmology
Al-Shifa Trust Eye Hospital
Farabi Eye Hospital
The First Affiliated Hospital of Guangxi Medical University
IUMS Pediatric Growth and Development Research Center
Hawler Medical University
National Cancer Institute Sri Lanka
Dr. Rajendra Prasad Centre for Ophthalmic Sciences
Dali University
Indus Hospital & Health Network
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
University of the Philippines Manila
Baghdad Teaching Hospital
University of Baghdad
Children's Hospital Lahore
Calcutta Medical Research Institute
Universitas Udayana
Universitas Airlangga
Universitas Gadjah Mada
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
American University of Beirut
King Hussein Cancer Center
The Aga Khan University
King Edward Medical University Lahore
Chang Gung Memorial Hospital
London School of Hygiene & Tropical Medicine
College of Medicine
Istanbul Üniversitesi
Chulalongkorn University
Kuala Lumpur Hospital
Sankara Nethralaya
Dhaka Medical College and Hospital
King George's Medical University
Gazi University, Faculty of Medicine
Seoul National University Hospital
Hacettepe Üniversitesi
King Khaled Eye Specialist Hospital
L.V. Prasad Eye Institute India
Indraprastha Apollo Hospitals
Great Ormond Street Hospital for Children NHS Foundation Trust
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Mahosot Hospital, Lao
Guangzhou Medical University
Ankara Üniversitesi
Ege University Medical School
Banaras Hindu University
Prince of Songkla University
Tel Aviv University
Bai Jerbai Wadia Hospital for Children
Seoul National University College of Medicine
Hadassah University Medical Centre
Scientific Center of Pediatrics and Pediatric Surgery
Dr. Shroff's Charity Eye Hospital
Imam Hussein Cancer Center
National Center of Oncology and Hematology
Basra Specialized Children Hospital
Tata Medical Center
Ibn Al Haitham Teaching Eye Hospital
National Center for Maternal and Child Health
National Centre of Ophthalmology Named after Acad. Zarifa Aliyeva
National Cancer Center of Uzbekistan
National Oncology Center
Wahidin Sudirohusodo Hospital
Susrut Eye Foundation and Research Centre
Cicendo Eye Hospital
National University of Medical Sciences
Narayana Health
Ramathibodi Hospital
Siriraj Hospital
Tilganga Institute of Ophthalmology
Al-Shifa Trust Eye Hospital
Farabi Eye Hospital
The First Affiliated Hospital of Guangxi Medical University
IUMS Pediatric Growth and Development Research Center
Hawler Medical University
National Cancer Institute Sri Lanka
Dr. Rajendra Prasad Centre for Ophthalmic Sciences
Dali University
Indus Hospital & Health Network
Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
University of the Philippines Manila
Baghdad Teaching Hospital
University of Baghdad
Children's Hospital Lahore
Calcutta Medical Research Institute
Universitas Udayana
Universitas Airlangga
Universitas Gadjah Mada
Universitas Indonesia, RSUPN Dr. Cipto Mangunkusumo
American University of Beirut
King Hussein Cancer Center
The Aga Khan University
King Edward Medical University Lahore
Chang Gung Memorial Hospital
London School of Hygiene & Tropical Medicine
College of Medicine
Istanbul Üniversitesi
Chulalongkorn University
Kuala Lumpur Hospital
Sankara Nethralaya
Dhaka Medical College and Hospital
King George's Medical University
Gazi University, Faculty of Medicine
Seoul National University Hospital
Hacettepe Üniversitesi
King Khaled Eye Specialist Hospital
L.V. Prasad Eye Institute India
Indraprastha Apollo Hospitals
Great Ormond Street Hospital for Children NHS Foundation Trust
Faculty of Medicine Ramathibodi Hospital, Mahidol University
Mahosot Hospital, Lao
Guangzhou Medical University
Ankara Üniversitesi
Ege University Medical School
Banaras Hindu University
Prince of Songkla University
Tel Aviv University
Bai Jerbai Wadia Hospital for Children
Seoul National University College of Medicine
Hadassah University Medical Centre
Scientific Center of Pediatrics and Pediatric Surgery
Dr. Shroff's Charity Eye Hospital
Imam Hussein Cancer Center
National Center of Oncology and Hematology
Basra Specialized Children Hospital
Tata Medical Center
Ibn Al Haitham Teaching Eye Hospital
National Center for Maternal and Child Health
National Centre of Ophthalmology Named after Acad. Zarifa Aliyeva
National Cancer Center of Uzbekistan
National Oncology Center
Wahidin Sudirohusodo Hospital
Susrut Eye Foundation and Research Centre
Cicendo Eye Hospital
Corresponding Author(s)
Other Contributor(s)
Abstract
Purpose: To describe the clinical presentation and treatment outcomes of children who received a diagnosis of retinoblastoma in 2017 throughout Asia. Design: Multinational, prospective study including treatment-naïve patients in Asia who received a diagnosis of retinoblastoma in 2017 and were followed up thereafter. Participants: A total of 2112 patients (2797 eyes) from 96 retinoblastoma treatment centers in 33 Asian countries. Interventions: Chemotherapy, radiotherapy, enucleation, and orbital exenteration. Main Outcome Measures: Enucleation and death. Results: Within the cohort, 1021 patients (48%) were from South Asia (SA), 503 patients (24%) were from East Asia (EA), 310 patients (15%) were from Southeast Asia (SEA), 218 patients (10%) were from West Asia (WA), and 60 patients (3%) were from Central Asia (CA). Mean age at presentation was 27 months (median, 23 months; range, < 1–261 months). The cohort included 1195 male patients (57%) and 917 female patients (43%). The most common presenting symptoms were leukocoria (72%) and strabismus (13%). Using the American Joint Committee on Cancer Staging Manual, Eighth Edition, classification, tumors were staged as cT1 (n = 441 [16%]), cT2 (n = 951 [34%]), cT3 (n = 1136 [41%]), cT4 (n = 267 [10%]), N1 (n = 48 [2%]), and M1 (n = 129 [6%]) at presentation. Retinoblastoma was treated with intravenous chemotherapy in 1450 eyes (52%) and 857 eyes (31%) underwent primary enucleation. Three-year Kaplan-Meier estimates for enucleation and death were 33% and 13% for CA, 18% and 4% for EA, 27% and 15% for SA, 32% and 22% for SEA, and 20% and 11% for WA (P < 0.0001 and P < 0.0001), respectively. Conclusions: At the conclusion of this study, significant heterogeneity was found in treatment outcomes of retinoblastoma among the regions of Asia. East Asia displayed better outcomes with higher rates of globe and life salvage, whereas Southeast Asia showed poorer outcomes compared with the rest of Asia. Financial Disclosure(s): The author(s) have no proprietary or commercial interest in any materials discussed in this article.