Exploring Clinical Remission in Moderate Asthma – Perspectives from Asia, the Middle East, and South America
Issued Date
2024-01-01
Resource Type
ISSN
23641754
eISSN
23641746
Scopus ID
2-s2.0-85195172275
Journal Title
Pulmonary Therapy
Rights Holder(s)
SCOPUS
Bibliographic Citation
Pulmonary Therapy (2024)
Suggested Citation
Maneechotesuwan K., Aggarwal B., Garcia G., Tan D., Neffen H., Javier R.J.M., Al-Ahmad M., Khadada M., Quan V.T.T., Teerapuncharoen K., Ramos M.S., Levy G., Plank M., Phansalkar A., Gibson P.G. Exploring Clinical Remission in Moderate Asthma – Perspectives from Asia, the Middle East, and South America. Pulmonary Therapy (2024). doi:10.1007/s41030-024-00262-2 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/98706
Title
Exploring Clinical Remission in Moderate Asthma – Perspectives from Asia, the Middle East, and South America
Author's Affiliation
Siriraj Hospital
GlaxoSmithKline Pharmaceuticals Ltd.
GlaxoSmithKline Australia Pty Ltd.
Mubarak Hospital
Kuwait University
Universidad Autónoma de Chihuahua
GlaxoSmithKline plc.
University of Newcastle, College of Health, Medicine and Wellbeing
John Hunter Hospital
Respiratory Research Center
Inmunología y Enfermedades Respiratorias
Emerging Markets
University of Medicine and Pharmacy
University of the East Ramon Magsaysay
University Medical Center
Hospital Ángeles Chihuahua
UERM Memorial Medical Center
GlaxoSmithKline Pharmaceuticals Ltd.
GlaxoSmithKline Australia Pty Ltd.
Mubarak Hospital
Kuwait University
Universidad Autónoma de Chihuahua
GlaxoSmithKline plc.
University of Newcastle, College of Health, Medicine and Wellbeing
John Hunter Hospital
Respiratory Research Center
Inmunología y Enfermedades Respiratorias
Emerging Markets
University of Medicine and Pharmacy
University of the East Ramon Magsaysay
University Medical Center
Hospital Ángeles Chihuahua
UERM Memorial Medical Center
Corresponding Author(s)
Other Contributor(s)
Abstract
Introduction: Clinical remission is a relatively new concept in asthma but recent research initiatives suggest it could be an ambitious and achievable therapeutic target for patients with asthma. Methods: In this modified Delphi study (comprising two online surveys, completed either side of a virtual scientific workshop), the opinions of a panel of respiratory physicians were evaluated to summarize perspective statements on key therapeutic outcomes and criteria for on-treatment clinical remission in patients with moderate asthma. An agreement threshold was pre-defined as agreement by ≥ 75% of participants. Results: Surveys 1 and 2 were completed by 20 and 18 participants, respectively. Most participants (95%) agreed with the concept of clinical remission in moderate asthma and that this should be a desirable treatment goal (90%). Based on a composite measure of 4–6 desirable therapeutic outcomes, current understanding of clinical remission was considered as 12 months with no exacerbations, no oral corticosteroids, no daytime or night-time asthma symptoms (Asthma Control Test score ≥ 20 or Asthma Control Questionnaire score ≤ 0.75), stable lung function, and no treatment-related adverse events. No agreement was reached on the role of relievers in defining therapeutic outcomes or on the wider use of biomarkers and airway hyperresponsiveness for defining asthma remission in clinical practice. Conclusions: In line with recent consensus statements from the United States and Europe, there was a high level of agreement on the elements of clinical remission among a panel of respiratory physicians from Asia, the Middle East, and South America. Extension of the concept of clinical remission to patients with moderate asthma was considered aligned with the potential of clinical remission as a goal of therapy.