Invasive aspergillosis in liver transplant recipients in the current era
Issued Date
2024-01-01
Resource Type
ISSN
16006135
eISSN
16006143
Scopus ID
2-s2.0-85200253600
Pubmed ID
38801991
Journal Title
American Journal of Transplantation
Rights Holder(s)
SCOPUS
Bibliographic Citation
American Journal of Transplantation (2024)
Suggested Citation
Kimura M., Rinaldi M., Kothari S., Giannella M., Anjan S., Natori Y., Phoompoung P., Gault E., Hand J., D'Asaro M., Neofytos D., Mueller N.J., Kremer A.E., Rojko T., Ribnikar M., Silveira F.P., Kohl J., Cano A., Torre-Cisneros J., San-Juan R., Aguado J.M., Mansoor A.e.R., George I.A., Mularoni A., Russelli G., Luong M.L., AlJishi Y.A., AlJishi M.N., Hamandi B., Selzner N., Husain S. Invasive aspergillosis in liver transplant recipients in the current era. American Journal of Transplantation (2024). doi:10.1016/j.ajt.2024.05.016 Retrieved from: https://repository.li.mahidol.ac.th/handle/20.500.14594/100404
Title
Invasive aspergillosis in liver transplant recipients in the current era
Author(s)
Kimura M.
Rinaldi M.
Kothari S.
Giannella M.
Anjan S.
Natori Y.
Phoompoung P.
Gault E.
Hand J.
D'Asaro M.
Neofytos D.
Mueller N.J.
Kremer A.E.
Rojko T.
Ribnikar M.
Silveira F.P.
Kohl J.
Cano A.
Torre-Cisneros J.
San-Juan R.
Aguado J.M.
Mansoor A.e.R.
George I.A.
Mularoni A.
Russelli G.
Luong M.L.
AlJishi Y.A.
AlJishi M.N.
Hamandi B.
Selzner N.
Husain S.
Rinaldi M.
Kothari S.
Giannella M.
Anjan S.
Natori Y.
Phoompoung P.
Gault E.
Hand J.
D'Asaro M.
Neofytos D.
Mueller N.J.
Kremer A.E.
Rojko T.
Ribnikar M.
Silveira F.P.
Kohl J.
Cano A.
Torre-Cisneros J.
San-Juan R.
Aguado J.M.
Mansoor A.e.R.
George I.A.
Mularoni A.
Russelli G.
Luong M.L.
AlJishi Y.A.
AlJishi M.N.
Hamandi B.
Selzner N.
Husain S.
Author's Affiliation
Centro de Investigación Biomédica en Red de Enfermedades Infecciosas
Siriraj Hospital
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
King Fahad Specialist Hospital, Dammam
The University of Queensland
Alma Mater Studiorum Università di Bologna
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Washington University School of Medicine in St. Louis
University of Miami Leonard M. Miller School of Medicine
Univerzitetni Klinični Center Ljubljana
UniversitatsSpital Zurich
Jackson Health System
University of Toronto
University Health Network
Hôpitaux Universitaires de Genève
Centre Hospitalier de L'Université de Montréal
Hospital Universitario 12 de Octubre
University of Pittsburgh School of Medicine
Siriraj Hospital
Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
King Fahad Specialist Hospital, Dammam
The University of Queensland
Alma Mater Studiorum Università di Bologna
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Washington University School of Medicine in St. Louis
University of Miami Leonard M. Miller School of Medicine
Univerzitetni Klinični Center Ljubljana
UniversitatsSpital Zurich
Jackson Health System
University of Toronto
University Health Network
Hôpitaux Universitaires de Genève
Centre Hospitalier de L'Université de Montréal
Hospital Universitario 12 de Octubre
University of Pittsburgh School of Medicine
Corresponding Author(s)
Other Contributor(s)
Abstract
Invasive aspergillosis (IA) is a rare but fatal disease among liver transplant recipients (LiTRs). We performed a multicenter 1:2 case-control study comparing LiTRs diagnosed with proven/probable IA and controls with no invasive fungal infection. We included 62 IA cases and 124 matched controls. Disseminated infection occurred only in 8 cases (13%). Twelve-week all-cause mortality of IA was 37%. In multivariate analyses, systemic antibiotic usage (adjusted odds ratio [aOR], 4.74; P = .03) and history of pneumonia (aOR, 48.7; P = .01) were identified as independent risk factors associated with the occurrence of IA. Moreover, reoperation (aOR, 5.99; P = .01), systemic antibiotic usage (aOR, 5.03; P = .04), and antimold prophylaxis (aOR, 11.9; P = .02) were identified as independent risk factors associated with the occurrence of early IA. Among IA cases, Aspergillus colonization (adjusted hazard ratio [aHR], 86.9; P < .001), intensive care unit stay (aHR, 3.67; P = .02), disseminated IA (aHR, 8.98; P < .001), and dialysis (aHR, 2.93; P = .001) were identified as independent risk factors associated with 12-week all-cause mortality, while recent receipt of tacrolimus (aHR, 0.11; P = .001) was protective. Mortality among LiTRs with IA remains high in the current era. The identified risk factors and protective factors may be useful for establishing robust targeted antimold prophylactic and appropriate treatment strategies against IA.